PhD Scientific Days 2024

Poster Session B - Pharmaceutical Sciences and Health Technologies 1.

Development and Formulation of Nanofiber-based Ophthalmic Inserts for the Treatment of Fungal Keratitis

Előadó neve

Ms. Musa, Safaa Mohammed Omer

Neptun code

JZ8Q8K

Előadó munkahelye

University Pharmacy, Department of Pharmacy Administration, Semmelweis University

Előadó telefonszáma

06707202835

Előadó e-mail címe

SAFOPHARMA111@GMAIL.COM

Az előadás címe

Development and Formulation of Nanofiber-based Ophthalmic Inserts for the Treatment of Fungal Keratitis

Szerző(k) neve és munkahelye

Safaa Mohammed Omer Musa¹, Nándor Nagy², Adrienn Kazsoki³, Romána Zélko³

1: Semmelweis Egyetem GyTK Egyetemi Gyógyszertár, Gyógyszerügyi Szervezési Intézet
2: Department of Anatomy, Histology and Embryology Semmelweis University, Tűzoltó Street 58, 1094 Budapest, Hungary
3: University Pharmacy, Department of Pharmacy Administration, Semmelweis University

Bemutatás módja

Poszter

Szekció

Poster Session B - Pharmaceutical Sciences and Health Technologies 1.

Language of the presentation

English

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction: Nanofiber-based ocular inserts are considered smart candidates for delivering various drugs and biopharmaceuticals to different layers of the eye, and they have good bioavailability compared to conventional ocular formulations such as eye drops.
Aim: The current study aimed at developing stable, preservative-free electrospun nanofiber-based ocular inserts of amphotericin B (AmphB) as a promising candidate for treating sight-threatening fungal keratitis.
Methods: The AmphB solubility was studied using cyclodextrin (γ-CD). The precursor solutions for electrospinning contain γ-CD to improve AmphB solubility, polyvinyl alcohol (PVA)as fibers forming polymer, and sodium taurocholate (STC) as permeation and solubility enhancer. By varying the amount of γ-CD, PVA, and STC, nine different formulations of AmphB-loaded fibers were prepared by electrospinning technique. The resulting samples were evaluated in terms of morphology, physicochemical characteristics, in vitro drug release, and cytocompatibility.
Results: The AmphB solubility was successfully increased using with γ-CD. From the phase solubility profile, it was observed that the solubility of AmpB was increased linearly as a function of γ-CD concentration to a specific limit (10% w/w of γ-CD). The solution was stable under heating for 2 hours at 60 °C. All samples were found to be fibrous, and increasing cyclodextrin concentration improved the fiber's morphology. FTIR suggested the formation of amorphous solid dispersion, which was confirmed by XRD. All formulations showed fast AmphB release and homogenous drug distribution.
Conclusion: The developed stable nanofibrous webs can be considered a promising candidate for AmphB ocular delivery and overcoming the ocular challenging barriers faced by conventional ocular formulations.
Funding: This project was supported by the National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund (ÚNKP-23-3-II-SE-2).

University

Semmelweis University

Supervisor

Prof. Dr. Romána Zelkó and Dr. Adrienn Katalin Nochta-Kazsoki

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6852

Start

15:00

End

15:03