PhD Scientific Days 2024

Mental Health Sciences III.

Association between kynurenine genetic pathway and migraine related hypersensitive brain networks

Előadó neve

Dr. Gecse, Kinga

Neptun code

X9LFNV

Előadó munkahelye

NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Department of Pharmacodynamics, Faculty of Pharmaceutical Sciences, Semmelweis University

Előadó telefonszáma

+36202969397

Előadó e-mail címe

gecse.kinga@semmelweis.hu

Az előadás címe

Association between kynurenine genetic pathway and migraine related hypersensitive brain networks

Szerző(k) neve és munkahelye

Kinga Gecse¹, Dóra Török¹, Bernadett Nagy¹, Gergely György Fedor¹, Gyorgy Bagdy¹, Gabriella Juhasz¹

1: NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Department of Pharmacodynamics, Faculty of Pharmaceutical Sciences, Semmelweis University

Bemutatás módja

Szóbeli

Szekció

Mental Health Sciences III.

Language of the presentation

Hungarian

Preferred session

Mental Health Sciences

Összefoglaló szövege

Introduction: Migraine attacks involve sensory hypersensitivity as a result of dysfunctional brain networks that persists in the interictal period. The periaqueductal gray matter (PAG) is one of the key regions involved in pain processing and modulation, thus contributing to migraine pathophysiology. Several neurotransmitters are thought to be responsible for the central sensitization in migraine. The neuroactive metabolites of kynurenine (KYN) pathway interacting with glutamatergic neurotransmission could modify the pain and sensory processing brain networks. Beside neuronal alterations, genetic factors are also important since migraine shows 40-60% of heritability.
Aims: Our aim was to identify the potential role of KYN pathway in migraine by integrating imaging, biological and genetic markers.
Methods: Twenty-four episodic, migraine without aura patients underwent a resting-state functional magnetic imaging session. Each participant’s functional connectivity (FC) map of PAG was calculated to investigate the alterations in pain and sensory processing networks. Blood samples were collected to measure plasma L-KYN concentration and genetic testing. The individual genetic risk of KYN pathway for migraine was described with a polygenic risk score (PRS). L- KYN concentration and KYN pathway PRS for migraine were used as covariates in regression models of PAG-FC analyses.
Results: Negative correlation was found between plasma L- KYN concentration and PAG-FC with superior occipital gyrus. The PRS of KYN pathway for migraine showed negative correlation between PAG-FC with cuneus.
Conclusions: Our results suggest that the KYN pathway plays a crucial role in migraine-related sensory hypersensitivity and hyperexcitability between the attacks. Previous studies showed that dysfunctional connection between PAG and occipital lobule is involved in multisensory processing deficit and in mind wandering away from pain. Thus, the association between the KYN pathway and decreased PAG-FC with occipital lobule indicates the involvement of KYN pathway in headache regulation through affecting cross-modal sensory processing networks. Therefore, the KYN pathway could serve as potential therapeutic target in migraine.
Funding: ÚNKP-23-4-I-SE-31; 2017-1.2.1-NKP-2017-00002; NAP2022-I-4/2022; TKP2021-EGA-25; OTKA (K143391); 2019-2.1.7-ERA-NET-2020-00005.

University

Semmelweis University

Supervisor

Gabriella Juhasz DSc; Gyorgy Bagdy DSc

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5972

Start

17:00

End

17:10