PhD Scientific Days 2024

Poster Session N - Cardiovascular Medicine and Research 2.

Feasibility of Coronary CT Angiography-based Fractional Flow Reserve Using a Clinical Photon Counting Detector CT System

Előadó neve

Dr. Zsarnoczay, Emese

Neptun code

a8vm14

Előadó munkahelye

Medical Imaging Centre, Semmelweis University

Előadó telefonszáma

06307138659

Előadó e-mail címe

zs.mese97@gmail.com

Az előadás címe

Feasibility of Coronary CT Angiography-based Fractional Flow Reserve Using a Clinical Photon Counting Detector CT System

Szerző(k) neve és munkahelye

Emese Zsarnóczay¹, Daniel Pinos², U. Joseph Schoepf², Nicola Fink², Jim O'Doherty², Milan Vecsey-Nagy², Pál Maurovich-Horvat¹, Tilman Emrich², Akos Varga-Szemes²

1: Medical Imaging Centre, Semmelweis University
2: Medical University of South Carolina

Bemutatás módja

Poszter

Szekció

Poster Session N - Cardiovascular Medicine and Research 2.

Language of the presentation

English

Preferred session

Cardiovascular Medicine and Research

Összefoglaló szövege

Introduction: Coronary computed tomography angiography (CCTA)-based fractional flow reserve (CT-FFR) allows for noninvasive determination of the functional severity of anatomic lesions in patients with coronary artery disease.
Aims: The aim of this study was to intra-individually compare CT-FFR between photon-counting detector (PCD) and conventional energy-integrating detector (EID) CT systems.
Method: In this single-center prospective study, subjects who underwent clinically indicated CCTA on an EID-CT system were recruited for a research CCTA on PCD-CT within 30 days. Image reconstruction settings were matched as closely as possible between EID-CT (Bv36 kernel, iterative reconstruction strength level 3, slice thickness 0.5mm) and PCD-CT (Bv36 kernel, quantum iterative reconstruction level 3, virtual monoenergetic level 55keV, slice thickness 0.6mm). CT-FFR was measured semi-automatically using a prototype on-site machine learning algorithm by two readers. CT-FFR analysis was performed per-patient and per-vessel, and a CT-FFR≤0.75 was considered hemodynamically significant.
Results: A total of 22 patients (63.3±9.2 years; 7 women) were included. Median time between EID-CT and PCD-CT was 5.5days. Comparison of CT-FFR values showed no significant difference and strong agreement between EID-CT and PCD-CT in the per-vessel analysis (0.88 [0.74-0.94] vs. 0.87 [0.76-0.93], P=0.096, mean bias 0.02, limits of agreement [LoA] -0.14/0.19, r=0.83, ICC=0.92), and in the per-patient analysis (0.81 [0.60-0.86] vs. 0.76 [0.64-0.86], P=0.768, mean bias 0.02, LoA -0.15/0.19, r=0.90, ICC=0.93). All included patients were classified into the same category (CT-FFR>0.75 vs ≤0.75) with both CT systems.
Conclusions: CT-FFR evaluation is feasible with PCD-CT and it shows a strong agreement with EID-CT-based evaluation when images are similarly reconstructed.

University

Semmelweis University

Supervisor

Pál Maurovich-Horvat, Akos Varga-Szemes

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5723

Start

16:40

End

16:43