PhD Scientific Days 2024

Poster Session G - Mental Health Sciences 2.

Trait Neuroticism Mitigates Genetic Susceptibility to Depression in Chronic Pain Patients: Results from GWAS and PRS Analyses

Előadó neve

Dr. Krause, Sándor

Neptun code

VF7BMM

Előadó munkahelye

Semmelweis University, Department of Pharmacodynamics

Előadó telefonszáma

+36203502541

Előadó e-mail címe

krause.sandor@phd.semmelweis.hu

Az előadás címe

Trait Neuroticism Mitigates Genetic Susceptibility to Depression in Chronic Pain Patients: Results from GWAS and PRS Analyses

Szerző(k) neve és munkahelye

Dr. Sándor Krause¹, Dóra Török¹, Zsófia Gál¹, Nóra Eszlári¹, György Bagdy¹, Gabriella Juhász¹, Xénia Gonda²

1: Semmelweis University, Department of Pharmacodynamics
2: Semmelweis University, Department of Psychiatry and Psychotherapy

Bemutatás módja

Poszter

Szekció

Poster Session G - Mental Health Sciences 2.

Language of the presentation

Hungarian

Preferred session

Mental Health Sciences

Összefoglaló szövege

Introduction: Chronic pain (CP) is frequently accompanied by depressive symptoms. Neuroticism, a tendency to experience negative emotions, can affect how we perceive and manage pain. However, information on the underlying genetics is still limited.

Aims: We planned to compare genetic predisposition to depression between the CP and non-pain (NP) groups by performing a genome-wide by trait interaction study, and to calculate polygenic risk scores (PRS) to examine how they predict depression.

Methods: We split the UK Biobank dataset (Application Number 1602) according to the prevalence of CP, and conducted genome-wide association studies (GWAS) for depression scores measured by the Patient Health Questionnaire, both as main effect and in interaction with neuroticism. Then, we calculated PRSs utilizing the NewMood dataset as target sample. We then tested the impact of PRSs on current and lifetime depression in various regression models, both per se and in interaction with neuroticism score. The above analyses were performed using PLINK 2, FUMA, R 4.1.2 and LDpred2.

Results: As for GWASs, only the SNP×Neuroticism interaction analyses yielded results meeting the genome-wide significance threshold: 2 SNPs in the CP and 42 SNPs in the NP group. Regarding the PRS analyses, current depression was affected by PRS_CP_interaction, while lifetime depression was affected by PRS_NP_main. In the latter case, PRS per se conferred susceptibility (beta=21.982; p=0.022), whereas the PRS:Neuroticism interaction term imposed a protective effect (beta=-0.326; p=0.039).

Conclusions: GWAS interaction analyses revealed a strong interaction effect of neuroticism and SNPs independently of CP. PRS_CP_interaction impacting current depression emphasizes the role of personality traits in the development of depressive symptoms. The link between lifetime depression and PRS_NP_main may imply differing aetiology for major depression and depression associated with CP. This underscores the heterogeneity of depression, highlighting the need of considering factors like personality and stress. Such an approach could advance personalized medicine and further deepen our understanding.

Funding: This study was supported by NAP2022-I-4/2022, K143391, 2019-2.1.7-ERA-NET-2020-00005, TKP2021-EGA-25, and the ÚNKP-23-3-I-SE-73 New National Excellence Program of the Ministry for Culture and Innovation.

University

Semmelweis University

Supervisor

Xénia Gonda

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8119

Start

14:50

End

14:53