PhD Scientific Days 2024

Poster Session B - Pharmaceutical Sciences and Health Technologies 1.

Development and characterization of a Nanofibrous Ophthalmic Insert for the Treatment of Age-related Macular Degeneration

Előadó neve

Dr. Nochta-Kazsoki, Adrienn Katalin

Neptun code

R5cdjv

Előadó munkahelye

University Pharmacy Department of Pharmacy Administration, Semmelweis University

Előadó telefonszáma

06302060093

Előadó e-mail címe

kazsoki.adrienn@semmelweis.hu

Az előadás címe

Development and characterization of a Nanofibrous Ophthalmic Insert for the Treatment of Age-related Macular Degeneration

Szerző(k) neve és munkahelye

Adrienn Katalin Nochta-Kazsoki¹, Noémi Anna Niczinger², Houssam Abboud¹, Nándor Nagy³, Romána Zelkó¹

1: University Pharmacy Department of Pharmacy Administration, Semmelweis University
2: Departments of Pharmaceutics, Semmelweis University
3: Department of the Anatomy, Histology and Embryology, Semmelweis University

Bemutatás módja

Poszter

Szekció

Poster Session B - Pharmaceutical Sciences and Health Technologies 1.

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction: The common cause of severe vision loss in old age is macular degeneration. As age progresses, blood supply and nutrient supply to the retina may decrease. To reduce the risk of vision loss, it is important to supply the retina with adequate micronutrients. Ophthalmic inserts containing lutein and antioxidant agents could be an alternative therapeutic option.
Aims: The aim of the project is to formulate a nanofibrous ophthalmic insert using electrospinning suitable for the treatment of age-related macular degeneration. A further objective was the morphological investigation, solid-state characterization of the obtained formulations, and examination of the ocular irritant activity.
Methods: The composite nanofibrous samples were prepared by coaxial electrospinning. Alfa-tocopherol-loaded phosphatidylcholine-derivate and cholesterol-based liposomes were formulated by ethanol injection method. The critical process and formulation parameters were investigated. The liposomes were characterized in terms of size distribution and zeta potential. As the shell part of the composite nanofiber Vitamin E containing liposome-loaded polyvinyl alcohol-poloxamer was chosen. As the core precursor lutein-loaded polylactic acid was used. The critical process and formulation parameters were investigated. The solid-state characterization was carried out and eye irritation test was investigated.
Results: Based on dynamic light scattering measurements it can be revealed successful liposome formulation. Combining the ethanol injection liposome preparation method with the extrusion technique better liposome characteristics were achieved. The results of the coaxial electrospinning fibrous samples were obtained. The cytocompatibility of the fibrous formulations was confirmed, as no irritation was found.
Conclusion: The developed electrospun fibrous sheet can enhance the supply of micronutrients to the retina, thus serving as an alternative or complementary treatment to orally administered vitamin supplements. Fibers are produced using a continuous, cost-effective, and highly controllable technology that can be fully integrated into modern pharmaceutical manufacturing.
Funding: This project was supported by ÚNKP-23-4-II-SE-22 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund.

University

Semmelweis University

Supervisor

Romána Zelkó

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8016

Start

15:20

End

15:23