PhD Scientific Days 2024

Mental Health Sciences I.

The Association Between ADHD Risk and Prospective Changes in Adolescent Callous-Unemotional Traits Moderated by Serotonergic Polymorphisms

Előadó neve

Sebők-Welker, Tünde

Neptun code

ITVHFZ

Előadó munkahelye

Semmelweis University Doctoral School of Mental Health Sciences, Psychiatry program

Előadó telefonszáma

0036707416806

Előadó e-mail címe

welker.tunde.eva@ttk.hu

Az előadás címe

The Association Between ADHD Risk and Prospective Changes in Adolescent Callous-Unemotional Traits Moderated by Serotonergic Polymorphisms

Szerző(k) neve és munkahelye

Sebők-Welker, Tünde É.¹, Bunford, Nóra²

1: Developmental and Clinical Neuropsychology Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, 1117 Budapest, Magyar Tudósok körútja 2, Hungary; Semmelweis University Doctoral School, Division of Mental Health Sciences, 1083 Budapest, Balassa u. 6, Hungary.
2: Developmental and Clinical Neuropsychology Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, 1117 Budapest, Magyar Tudósok körútja 2, Hungary

Bemutatás módja

Szóbeli

Szekció

Mental Health Sciences I.

Language of the presentation

English

Preferred session

Mental Health Sciences

Összefoglaló szövege

Introduction - Callous-unemotional (CU) traits, characterized by shallow affect, lack of empathy, and fearlessness, are associated with ADHD and related disorders like ODD, CD, and ASPD. The serotonergic system, involving serotonin and related genes (e.g., SLC6A4, HTR1A), plays a key role in mood regulation and behavior. Research indicates that polymorphisms like 5-HTTLPR and HTR1B are linked to ADHD and CU traits, with varying effects based on genetic variations. Existing studies suggest that CU traits mediate the association between 5-HTTLPR and ADHD, highlighting the need for further investigation.
Aims - Aim was to examine whether accounting for self-reported negative affectivity (NA) and parent-reported oppositional defiant disorder (ODD) symptoms as relevant covariates, parent-reported ADHD risk moderates the association between serotonergic polymorphisms and prospective changes in self-reported CU traits in adolescents. Multi-locus genetic profile (MLGP) scores captured the combined effect of included polymorphisms.
Methods - Data from a larger longitudinal study were analyzed. Participants (243 adolescents) underwent cognitive, clinical, genetic, and questionnaire assessments. ADHD risk was determined using the parent-rated ADHD Rating Scale-5, with classifications based on symptom criteria. Genotyping for serotonergic polymorphisms (HTTLPR, HTR1B) was performed.
Results - The robust regression model with 5HTTLPR polymorphism predicted: ΔCallousness scores, with a positive association of ΔUncaring and ADHD risk by 5HTTLPR polymorphism interaction with ΔCallousness scores; ΔUncaring scores, with a positive association of ΔCallousness with ΔUncaring scores. The robust regression model with the serotonergic MLGP score predicted: ΔCallousness scores, with a positive association of ΔUncaring and negative association of the ADHD risk by serotonergic MLGP score interaction with ΔCallousness scores; ΔUncaring scores, with a positive association of ΔCallousness with ΔUncaring scores.
Conclusion – Serotonergic polymorphisms differentially confer risk on CU traits based on ADHDrisk status.
Funding – ST was funded by a New National Excellence Programme (ÚNKP-23-3-II-SE-19) and SE250+ fellowships.

University

Semmelweis University

Supervisor

Dr. Bunford Nóra

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7490

Start

11:30

End

11:40