PhD Scientific Days 2024
Budapest, 9-10 July 2024
Conservative Medicine
The mysterious twists of the umbilical cord
Előadó neve
Dr. Zsáry, Eszter
Neptun code
ud20zk
Előadó munkahelye
Department of Neonatology, Pediatric Centre Semmelweis University
Előadó telefonszáma
06308300096
Előadó e-mail címe
zsary.eszter@stud.semmelweis.hu
Az előadás címe
The mysterious twists of the umbilical cord
Szerző(k) neve és munkahelye
Eszter Zsáry1, Enikő Mózes2, Tamás Marton3, Beáta Hargitai3, Miklós Szabó2
1: Department of Neonatology, Pediatric Centre Semmelweis University
2: Department of Obstetrics and Gynaecology, Semmelweis University; Department of Neonatology, Pediatric Centre Semmelweis University
3: Department of Obstetrics and Gynaecology, Semmelweis University; Department of Pathology, Forensic-, and Insurance Medicine, Semmelweis University
Bemutatás módja
Szóbeli
Szekció
Conservative Medicine
Language of the presentation
English
Preferred session
Conservative Medicine
Összefoglaló szövege
Introduction
Perinatal complications are leading causes of loss of disability-adjusted life years (DALYs). Previous observations suggest that umbilical cord (UC) pathology, including hypo-coiling (HC-) and hyper-coiling (HC+), are associated with stillbirth and neonatal morbidity. However, the epidemiology and associations of these are poorly understood.
Aims
To describe the epidemiology of macroscopic characteristics of the UC based on the observation of 2000 placentas. To investigate the associations between UC parameters and placental morphology, and clinical data.
Method
This is an interim, preliminary analysis. Macroscopic examination of 180 placentas and UCs was performed based on the Amsterdam consensus criteria, during a 3-month period (2024), from singleton live births at the Dep. of Obs. and Gyn. of Semmelweis University. Out of these, 30(16,7%) were referred to routine pathological examination (high-risk pregnancies). HC- and HC+ were defined as less than 1 or more than 3 coils per 10 cm respectively, based on measurement of the whole cord. Related clinical data and results of pathological examination were collected and stored in REDCap. Statistics: Independent-Samples T Test, Chi square test, and Spearman correlation.
Results
Mean (±SD) gestational age was 38,3 (±2,5), min.=23, max.=41 weeks. Vaginal delivery was in 99(55,0%), while caesarean section in 81(45,0%) cases. We observed HC+ in n=20(11,1%), HC- in n=34(18,9%), true knot in n=1(0,6%), single umbilical artery in n=2(2,1%), abnormal cord insertion in n=39(21,7%) cases. As expected, gestational age, placental weight, birth weight and length of the cord positively correlated, and there was association between birth weight percentile and placental weight. HC+ was associated with focal placental lesions (p=0,004). HC+ was twice as frequent (20% vs. 9%) in high-risk pregnancies than in lower risk pregnancies. There was a tendency of association between IUGR and HC+.
Conclusion
This preliminary data suggests that hyper-coiled umbilical cords are associated with higher rate of macroscopic placental lesions and may have an adverse impact on fetal growth. This data supports our basic hypothesis that HC+ is a clinically relevant phenomenon.
Funding
RRF-2.3.1-21-2022-00011 (Translational Neuroscientific National Laboratory project within the framework of Széchenyi Terv Plusz Program)
University
Semmelweis University
Supervisor
Prof. Dr. Miklós Szabó
Publication of my abstract
I give consent to the publication of my abstract on the website of the congress.
Kind
Szabad
Status
elfogadva
Accepted presentation method
szóbeli
Előadás fájl jóváhagyás
nem rendelkezett róla
Előadó
8112
Start
12:15
End
12:25