PhD Scientific Days 2024

Poster Session B - Pharmaceutical Sciences and Health Technologies 1.

Development of an AAV bioproduction technological platform in microalgae

Előadó neve

Esnard, Marie, PhD

Előadó munkahelye

INSERM UMR1089 Laboratory TaRGeT and CNRS UMR6144 Laboratory GEPEA

Előadó telefonszáma

0631649956

Előadó e-mail címe

marie.esnard@etu.univ-nantes.fr

Az előadás címe

Development of an AAV bioproduction technological platform in microalgae

Szerző(k) neve és munkahelye

M.Esnard^1,2, S.Bolik¹, M. Renaudie², J. Pruvost², L. Marchal², O. Adjali¹

1: Laboratory TaRGeT, UMR1089 INSERM, Nantes, 44200, France.
2: Laboratory GEPEA, UMR6144 CNRS, Saint-Nazaire, 44600, France.

Bemutatás módja

Poszter

Szekció

Poster Session B - Pharmaceutical Sciences and Health Technologies 1.

Language of the presentation

English

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Recombinant adeno-associated viral vectors (rAAV) are vehicles of choice for in vivo gene therapy approaches. The success of clinical trials using rAAV for the treatment of rare genetic diseases has led to the commercialization of already six rAAV-based next-generation therapies capable of treating the genetic cause of many previously incurable pathologies. Today's scientific advances make it possible to treat more complex diseases using systemic routes of administration, for which the necessary doses of rAAV are increasingly important. The field of rAAV manufacturing is thus facing new challenges: producing quality viral vectors, in large quantity and at reduced cost. Existing technologies for rAAV manufacturing are effective, but remain extremely costly when the product achieves the commercial scale because of the need of highly complex culture media. Microalgae are eukaryotic organisms that can produce bioproducts in the presence of minimal requirement (light and simple media). Microalgae large scale culture system in bioreactors are already applied on an industrial scale for the production of recombinant proteins. The GREEN-AAV project (under the national initiative Grand défi Bioproduction) is an ambitious and innovative project aiming at the evaluation of the feasibility and potential of a new microalgae cellular platform for rAAV manufacturing.

University

Nantes Université

Supervisor

L.Marchal

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8241

Start

15:40

End

15:43