PhD Scientific Days 2024

Poster Session M - Cardiovascular Medicine and Research 1.

The effect of excessive trabeculation on cardiac rotation – a multimodal imaging study

Előadó neve

Dr. Grebur, Kinga

Neptun code

GT9FR1

Előadó munkahelye

Semmelweis University, Heart and Vascular Center

Előadó telefonszáma

06300164371

Előadó e-mail címe

gkinga9611@gmail.com

Az előadás címe

The effect of excessive trabeculation on cardiac rotation – a multimodal imaging study

Szerző(k) neve és munkahelye

Kinga Grebur¹, Balázs Mester¹, Márton Horváth¹, Kristóf Farkas-Sütő¹, Zsófia Gregor¹, Anna Réka Kiss¹, Attila Tóth¹, Attila Kovács¹, Alexandra Fábián¹, Bálint Károly Lakatos¹, Bálint András Fekete², Csaba Bödör², Katalin Csonka², Béla Merkely¹, Hajnalka Vágó¹, Andrea Szűcs¹

1: Semmelweis University, Heart and Vascular Center
2: Semmelweis University, Department of Pathology and Experimental Cancer Research

Bemutatás módja

Poszter

Szekció

Poster Session M - Cardiovascular Medicine and Research 1.

Language of the presentation

Hungarian

Preferred session

Cardiovascular Medicine and Research

Összefoglaló szövege

Introduction
Cardiac rotational parameters in primary left ventricular noncompaction (LVNC) with preserved left ventricular ejection fraction (LVEF) are not well understood.
Aims
We aimed to analyze cardiac rotation measured with cardiac magnetic resonance feature-tracking (CMR-FT) and speckle-tracking echocardiography (Echo-ST) in LVNC morphology subjects with preserved LVEF and different genotypes and healthy controls.
Method
Our retrospective study included 54 LVNC subjects with preserved LVEF and 54 control individuals. We evaluated functional and rotational parameters with CMR in the total study population and with echocardiography in 39 LVNC and 40 C individuals. All LVNC subjects were genotyped with a 174-gene next-generation sequencing panel and grouped into the subgroups: benign (B), variant of uncertain significance (VUS), and pathogenic (P).
Results
In comparison with controls, LVNC subjects had reduced apical rotational degree and one-third had negative apical rotation. While the degree of apical rotation was comparable between the three genetic subgroups, they differed significantly in the direction of apical rotation. In contrast to control and B groups, all four studied cardiac rotational patterns were identified in the P and VUS subgroups, namely normal rotation, positive and negative rigid body rotation, and reverse rotation. When the CMR-FT and Echo-ST methods were compared, the direction and pattern of cardiac rotation had moderate to good association whereas the rotational degrees showed no reasonable correlation or agreement.
Conclusion
While measuring cardiac rotation using both CMR-FT and Echo-ST methods, subclinical mechanical differences were identified in subjects with LVNC phenotype and preserved LVEF, especially in cases with genetic involvement.
Funding
The research was supported by the ÚNKP-23-3-II new national excellence program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund; by the EFOP-3.6.3-VEKOP-16-2017-00009; by the TKP2021-NKTA-46 and by the TKP2021-NKTA funding scheme.

University

Semmelweis University

Supervisor

Andrea Szűcs PhD

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6844

Start

16:45

End

16:48