PhD Scientific Days 2024

Poster Session I - Neurosciences 2.

Lag-structure in fMRI across three psychiatric groups: resting-state, state-dependency and clinical-behavioral correlates

Előadó neve

Dr. Tarchi, Livio

Előadó munkahelye

University of Florence, Psychiatry Unit

Előadó telefonszáma

3716731497

Előadó e-mail címe

livio.tarchi@unifi.it

Az előadás címe

Lag-structure in fMRI across three psychiatric groups: resting-state, state-dependency and clinical-behavioral correlates

Szerző(k) neve és munkahelye

Livio Tarchi¹, Stefano Damiani², Paolo LaTorracaVittori², Giovanni Castellini¹, Pierluigi Politi², Paolo FusarPoli², Valdo Ricca¹

1: University of Florence
2: University of Pavia

Bemutatás módja

Poszter

Szekció

Poster Session I - Neurosciences 2.

Language of the presentation

English

Preferred session

Neurosciences

Összefoglaló szövege

Introduction:
fMRI measures beyond zero-lag functional connectivity could serve as useful tools for understanding the distinct spatio-temporal dynamics characterizing psychiatric conditions.

Aims:
The primary objective was to compare lag-structure at resting-state between 95 healthy controls and three psychiatric conditions (35 ADHD, 38 bipolar disorder and 23 schizophrenia patients, DSM-IV-TR diagnosis). The secondary aims were to investigate whether and how state-dependence influences lag-structure in healthy controls and clinical-behavioral correlates of lag-structure in psychiatric groups.

Methods:
Lag-structure was computed from cross-correlation coefficients in resting-state and stop-signal task scans. Between and within-group differences were compared through non-parametric tests. Correlations with clinical-behavioral parameters were evaluated using linear regressions (Brief Psychiatric Rating Scale - BPRS, task reaction time).

Results:
Compared to healthy controls, lag-structure within default-mode, executive-control and salience networks was generally increased in ADHD (min Z-score -3.983), generally decreased in Schizophrenia (min Z-score -3.716) and with mixed increases/decreases in Bipolar patients (min Z-score -3.912, max 4.739). Widespread state-dependent reductions of lag-structure across the whole brain were observed across all groups from rest to task (max Q-statistics: healthy controls 58; ADHD 22; Bipolar 26; Schizophrenia 17). Correlations with clinical-behavioral variables (BPRS, reaction time) were positive in executive-control network and negative in bilateral thalamus for ADHD, negative in the cerebellum for Schizophrenia and positive in right temporal gyri, amygdala, hippocampus, and cerebellum for Bipolar (p=0.05).

Conclusion:
Differences in lag-structure in comparison to healthy controls progressively increased in magnitude from ADHD to Bipolar Disorder and Schizophrenia. Clinical groups exhibited different lag-structure state-dependence in executive-control, salience, and default-mode regions.

Funding:
no funding was received

University

University of Florence

Supervisor

Prof. Giovanni Castellini

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8246

Start

15:40

End

15:43