PhD Scientific Days 2024

Poster Session B - Pharmaceutical Sciences and Health Technologies 1.

Ionic liquids as a new molecular carriers for anticancer drugs

Előadó neve

Eduardo, Iniesta-López, PhD

Előadó munkahelye

University of Murcia

Előadó telefonszáma

+0034605276961

Előadó e-mail címe

eduardo.iniestal@um.es

Az előadás címe

Ionic liquids as a new molecular carriers for anticancer drugs

Szerző(k) neve és munkahelye

Eduardo Iniesta López¹, Adrian Hernández Fernández¹, Yolanda Garrido¹, Ana Sanchez Zurano¹, Antonia Pérez de los Ríos¹, Francisco Jose Hernández Fernández¹

1: University of Murcia

Bemutatás módja

Poszter

Szekció

Poster Session B - Pharmaceutical Sciences and Health Technologies 1.

Language of the presentation

English

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

A drawback that the pharmaceutical industry faces when developing drug delivery systems relates to the low solubility of many drugs and even low absorption in the target tissue. Today, new carriers like nanoparticles are being developed and applied. However, these can present toxicity, elimination problems once they have penetrated the body and difficulty in crossing membranes and reaching target tissues. Our proposal lies on the use of molecular drug carriers and especially those known as ionic liquids and deep eutectic solvents. These are molecules with unique solvent properties which result in less toxicity of medical treatments, less side effects, greater effectiveness of drugs, reduction in the amount of active ingredients used and even less environmental pollution by being able to be used in less quantity and ultimately a better quality of life of the citizen. These new molecular carriers will be studied on lurbinectedin (ZEPZELCA™) as a model molecule which is a new anticancer drug. Lurbinectedin presents problems of solubility, side effects and toxicity, problems common to most medicines. This work also aims to develop a new working methodology for the development of new molecular carriers based on ionic liquids and deep eutectic solvents for other types of drugs. One of the first steps is to select non-toxic and biocompatible ionic liquids. In this work, using previously published toxicity data, quantitative structure–property relationship models have been developed to assess the factors that govern the toxicity of a range of different ionic liquids to one aquatic organism, Vibrio fischeri. The results were well correlated for this organism (r2>0.99). It was found that: (i) a decrease in the alkyl chain length of the alkyl substituent of the cation involves a decrease in IL toxicity, (ii) the inclusion of an heteroatom in the alkyl substituent of the cation involves a decrease in IL toxicity, (iii) ionic liquids containing a non-aromatic carbon ring are less toxic than those containing aromatic carbon rings. Therefore, the adjustable nature of ionic liquids, and the structure–toxicity relationship found would allow the design of more environmentally friendly ionic liquids.Funding: This work is developing with the financial support of the University of Murcia (Ayuda Complementaria de Investigación 2022-2023).

University

University of Murcia

Supervisor

Antonia Perez De Los Rios

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8245

Start

15:50

End

15:53