PhD Scientific Days 2024

Poster Session T - Cardiovascular Medicine and Research 3.

Evaluating the Predictive Value of Late Gadolinium Enhancement assessed by Cardiac Magnetic Resonance on Sudden Cardiac Death in Patients selected for Implantable Cardioverter Defibrillator and Cardiac Resynchronization Therapy Implantation: a Systematic review and Meta-analysis

Előadó neve

Dr. Masszi, Richárd

Neptun code

e6skpl

Előadó munkahelye

Semmelweis University Heart and Vascular Center

Előadó telefonszáma

06304997593

Előadó e-mail címe

masszi.richard@gmail.com

Az előadás címe

Evaluating the Predictive Value of Late Gadolinium Enhancement assessed by Cardiac Magnetic Resonance on Sudden Cardiac Death in Patients selected for Implantable Cardioverter Defibrillator and Cardiac Resynchronization Therapy Implantation: a Systematic review and Meta-analysis

Szerző(k) neve és munkahelye

Masszi Richárd¹, Zsigmond Előd János², Ehrenberger Réka¹, Turan Caner³, Fehérvári Péter³, Teutsch Brigitta³, Molnár Zsolt³, Drobni Zsófia⁴, Hajnalka Vágó⁴, Hegyi Péter³, Merkely Béla⁴, Kosztin Annamária⁴

1: Semmelweis University Heart and Vascular Center, Centre for Translational Medicine
2: Department of Cardiology, Military Hospital
3: Semmelweis University Centre for Translational Medicine
4: Semmelweis University Heart and Vascular Center

Bemutatás módja

Poszter

Szekció

Poster Session T - Cardiovascular Medicine and Research 3.

Language of the presentation

English

Preferred session

Cardiovascular Medicine and Research

Összefoglaló szövege

Introduction: Late gadolinium enhancement (LGE) assessed by cardiovascular magnetic resonance (CMR) can evaluate myocardial scar associated with a higher risk of sudden cardiac death (SCD), which can guide the selection between cardiac resynchronization therapy with or without a defibrillator (CRT-P/CRT-D).
Aims: Our aim was to investigate the association between LGE and SCD risk in patients with CRT using the LGE-CMR technique.
Methods: We performed a systematic literature search using four databases. The target population was CRT candidates. The primary endpoint was SCD. The risk of bias was assessed using the QUIPS tool.
Results: Fifteen eligible articles were included with a total of 2494 patients, of whom 27%, 56%, and 19% had an implantable cardioverter defibrillator (ICD), CRT-D, and CRT-P, respectively. Altogether, 54.71% of the cohort was LGE positive, who had a 72% higher risk for SCD (HR 1.72; 95% CI 1.18-2.50) compared to LGE negatives. In non-ischemic patients, the proportion of LGE positivity was 46.6%, with a significantly higher risk for SCD as compared to LGE negatives (HR 2.42; 95% CI 1.99-2.94). The subgroup of CRT-only patients showed no difference between the LGE-positive vs. negative candidates (HR 1.17; 95% CI 0.82-1.68). Comparable SCD risk was observed between articles with short- (OR 7.47; 95% CI 0.54-103.12) vs. long-term (OR 6.15; 95% CI 0.96-39.45) follow-up time.
Conclusion: LGE-CMR positivity was associated with an increased SCD risk; however, in CRT candidates, the difference in risk reduction between LGE positive vs. negative patients was statistically not significant, suggesting a role of reverse remodeling. LGE-CMR before device implantation could be crucial in identifying high-risk patients even in non-ischemic etiology.

University

Semmelweis University

Supervisor

Kosztin Annamária

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6887

Start

16:45

End

16:48