PhD Scientific Days 2024

Molecular Medicine II.

The Innate Immunity-Gut-Microbiota Axis as a Key Target for Aging in Zebrafish.

Előadó neve

Mr. Juan Francisco, Rodriguez Vidal

Előadó munkahelye

University of Murcia

Előadó telefonszáma

+34647979810

Előadó e-mail címe

juanfrancisco.rodriguez3@um.es

Az előadás címe

The Innate Immunity-Gut-Microbiota Axis as a Key Target for Aging in Zebrafish.

Szerző(k) neve és munkahelye

Juan Francisco Rodriguez-Vidal¹, Diana García-Moreno², Isabel Cabas¹, Maria Luisa Cayuela², Alfonsa García-Ayala¹, Victoriano Mulero¹

1: University of Murcia, Spain.
2: IMIB Pascual Parrilla, Spain.

Bemutatás módja

Szóbeli

Szekció

Molecular Medicine II.

Language of the presentation

English

Preferred session

Molecular Medicine

Összefoglaló szövege

Aging is a multifaceted process that involves a decline in functionality and integrity. Among others, it triggers the development of a chronic inflammatory state and gut dysbiosis1. rag1 mutant zebrafish has been reported to develop accelerated aging characterized by increased expression of inflammatory and apoptotic markers and systemic macrophage infiltration, likely due to over-activation of innate immunity 3. Aiming to deepen the potential roles of microbiota in inflammatory aging, rag1 mutant zebrafish was used to perform a variety of omic technologies together with histological and enzymatic analyses. The results showed a reduced villi length and goblet cell number in the intestine of rag1 mutants together with several changes in genes related to lipid metabolism (slc5a8l), eicosanoid production (lta4h, ptges) and apoptosis (casp6a, casp6b.1), which correlated with higher caspase-6 activity. Alongside with this, a reduced bacterial diversity, increased Proteobacteria and decreased Fusobacteria abundance, together with a reduction in genes related to short-chain fatty acid metabolism was observed in the gut microbiota of rag1 mutants. The evidences presented in this study show that in the absence of lymphocytes, the gut microbiota and intestinal homeostasis undergo significant and detrimental changes. These findings shed light on the critical interplay between the gut microbiota and host immunity, offering novel therapeutic approaches for age-related diseases.

University

University of Murcia

Supervisor

Victoriano Mulero

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8253

Start

18:00

End

18:10