PhD Scientific Days 2024

Dental Research

Prevalence of Periopathogenic Porphyromonas Gingivalis Bacterium in Cardiovascular Samples with Different Oral Status: a Meta-Analysis

Előadó neve

Dr. Kelly, Caroline

Neptun code

RHX40I

Előadó munkahelye

Department of Restorative Dentistry and Endodontics

Előadó telefonszáma

00353871017937

Előadó e-mail címe

caroline.kelly@stud.semmelweis.hu

Az előadás címe

Prevalence of Periopathogenic Porphyromonas Gingivalis Bacterium in Cardiovascular Samples with Different Oral Status: a Meta-Analysis

Szerző(k) neve és munkahelye

Caroline Kelly¹, Eniko V. Szabo¹, Petrana Martinekova¹, Yasir Nabeel Al-Mohammad¹, Mojtaba Dahmardeh¹, Marton Kivovics¹, Szilvia Kiss-Dala¹, Gabor Varga¹, Peter Hegyi¹, Beata Keremi¹, Zsolt M. Lohinai¹

1: Semmelweis University

Bemutatás módja

Szóbeli

Szekció

Dental Research

Language of the presentation

English

Preferred session

Dental Research

Összefoglaló szövege

Intro: Cardiovascular disease (CVD) claims 18 million lives each year. Periodontitis, affecting up to 50% of the population, is associated with an elevated risk of CVD, including atherosclerosis, hypertension, endocarditis, and heart attacks etc. The severity of periodontitis correlates with an increased risk of CVD. One contributing factor is Porphyromonas gingivalis (Pg), an oral pathogenic bacterium, can disrupt lipid levels and damage endothelial cells, further increasing the risk.

Aim: To determine the prevalence of Pg in surgical samples of adults with CVD needing surgical intervention compared to healthy vessel samples.

Methods: We followed PRISMA guidelines for the systematic search. After full text selection and data extraction the proportion of patients with prevalence of Pg in CV samples was calculated using random-effects meta-analyses. Multiple subgroup analyses were performed.

Results: Twenty-five articles were included and subgrouped according to the study population presenting healthy periodontium, periodontitis or edentulousness. The articles detailing periodontitis in patients were further subgrouped by surgeries at various CV sites: heart, coronary artery, aorta, and carotid artery. The control group consisted of samples taken from healthy vessels. Our results show that Pg was found in CV lesions of patients with healthy periodontium in 11% (0.01-0.53) with 0% heterogenity (I2 ) and in periodontitis in 23% (0.13-0.36) with I2 80%, which could be explained by the diversity of the sample size, the location of the CV lesion and the different sensitivity of the PCR techniques used in the studies. In edentulous subgroups, there were too few articles for statistical analysis. In the coronary artery subgroup of patients with periodontitis the prevalence of Pg was 40% (0.23-0.60), the highest among the vessels. Followed by the aorta and the carotid artery with 18% (0.01-0.81) and 14% (0.02-0.56), respectively. The test for subgroup differences suggests a significant subgroup effect (p<0.001). Heart sample number was not enough for statistics.

Conclusion: Pg can be found in CV samples, suggesting a role in the pathogenesis of CVD. Coronary arteries are more susceptible to Pg compared to other investigated arteries. These results highlight the importance of oral hygiene and health in preventing life-threatening conditions.

Funding: N/A

University

Semmelweis University

Supervisor

Zsolt M. Lohinai, Beata Keremi, Eniko V. Szabo

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8249

Start

10:30

End

10:40