PhD Scientific Days 2024

Poster Session N - Cardiovascular Medicine and Research 2.

Photon-Counting CT for the detection of obstructive coronary artery disease: a diagnostic accuracy analysis

Előadó neve

Dr. Boussoussou, Melinda

Neptun code

IMK4SC

Előadó munkahelye

Semmelweis University Heart and Vascular Center

Előadó telefonszáma

0036206632859

Előadó e-mail címe

melinda.b.md@gmail.com

Az előadás címe

Photon-Counting CT for the detection of obstructive coronary artery disease: a diagnostic accuracy analysis

Szerző(k) neve és munkahelye

Melinda Boussoussou¹, Borbála Vattay¹, Norbert Nagy², Judit Simon², Zsófia Jokkel¹, Bálint Szilveszter¹, Béla Merkely¹, Pál Maurovich-Horvat²

1: Semmelweis University Heart and Vascular Center
2: Semmelweis University Medical Imaging Center

Bemutatás módja

Poszter

Szekció

Poster Session N - Cardiovascular Medicine and Research 2.

Language of the presentation

Hungarian

Preferred session

Cardiovascular Medicine and Research

Összefoglaló szövege

Introduction: The novel photon counting detector computed tomography(PCD-CT) with increased spatial resolution, and reduced beam-hardening artifact created a new field in coronary stenosis assessment compared to the energy-integrating detector CT(EID-CT). Aims:In our study, we aimed to evaluate the diagnostic accuracy of PCD-CT compared to the EID-CT using invasive coronary angiography(ICA) as the reference standard. Methods: We enrolled patients with stable chest pain and≥50% stenosis on PCCT who subsequently underwent ICA at our tertiary center. The per-vessel sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV), and diagnostic accuracy(DA) of PCCT were calculated for detecting≥50% or≥70% stenosis with ICA as the reference. The same analysis was conducted in a group of patients with EID-CT. Results: A total of 200 vessels were evaluated involving 4 different coronary segments: left main, left anterior descending artery, left circumflex artery and right coronary artery. The diagnostic performance of PCCT for detecting ≥50% stenosis was as follows: sensitivity 96.67%(91%CI[88.47%-99.59%]), specificity 85.00% (95%CI[77.99% -90.47%]), PPV 73.42%(95%CI[64.99%-80.42%]), NPV 98.35%(95%CI[93.83%-99.57%]), DA 88.50%(95%CI[83.25%-92.57%]). While diagnosing ≥70% stenosis, the sensitivity 100.00%(91%CI[91.96%-100.00%]), specificity 91.03%(95%CI[85.40%-95.01%]), PPV was 75.86%(95%CI[65.60%-83.82%]), NPV was 100.00% (95% CI [97.44% to 100.00%]) and the DA was 93.00%(95%CI[88.53% to 96.12%]). Using EID-CT for the identification of≥50% stenosis the following results were present: sensitivity 96.88%(91% CI [89.16%-99.62%]), specificity 71.32% (95%CI [62.95%-78.75%]), PPV 61.39% (95%CI[54.86%-67.53%]), NPV 97.98% (95%CI[92.51%-99.48%]), DA 79.50%(95% CI[73.23%-84.87%]), whereas identifying vessels with ≥70% luminal narrowing: sensitivity 84.62% (91%CI [71.92%-93.12%]), specificity 81.08% (95%CI [73.83%-87.05%]), PPV 61.11%(95%CI[52.47%-69.11%]), NPV 93.75%(95%CI 88.75%-96.61%]), and 82.00%(95%CI[75.96%-87.06%]) DA were found.
Conclusions: The PCCT scanner provides excellent diagnostic performance in detecting obstructive coronary artery disease, in a per-vessel analysis, furthermore PCCT proved to have better diagnostic accuracy when compared to EID-CT.Funding: MB was was supported by the ÚNKP-23-4-I-SE-23 New National Excellence Program

University

Semmelweis University

Supervisor

Dr. Bálint Szilveszter, Dr. Pál Maurovich-Horvat

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4775

Start

16:50

End

16:53