PhD Scientific Days 2025

Poster Session I. - N: Health Sciences

Investigating the Effect of Regular Training on Changes of Bone-related Biomarkers in Healthy Population - Systematic Review and Meta-Analysis

Előadó neve

Barna Viktoria, MSc

Neptun code

QDWQUW

Előadó munkahelye

Centre for Translational Medicine

Előadó telefonszáma

+36309287919

Előadó e-mail címe

barna.viktoria2@semmelweis.hu

Az előadás címe

Investigating the Effect of Regular Training on Changes of Bone-related Biomarkers in Healthy Population - Systematic Review and Meta-Analysis

Szerző(k) neve és munkahelye

Viktória Barna^1,2,3, Amir Makolli^1,2,3, Zsuzsanna Pásztorné Benyó^1,2,4, Marie Anne Engh¹, Ádám Zolcsák^1,5, Brigitta Teutsch^1,6,7, Vivienne Seymour², Péter Hegyi^7,8, Renáta Papp^1,2,3,9, Nóra Sydó^1,10, Péter Ferdinandy^1,2

1: Centre for Translational Medicine, Semmelweis University, Budapest, Hungary
2: Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
3: Center for Pharmacology and Drug Research & Development, Semmelweis University, Budapest, Hungary
4: enter for Pharmacology and Drug Research & Development, Semmelweis University, Budapest, Hungary
5: Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
6: Department of Radiology, Medical Imaging Centre, Semmelweis University, Korányi Sándor U. 2, 1082, Budapest, Hungary.
7: Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary
8: 1Centre for Translational Medicine, Semmelweis University, Budapest, Hungary
9: Centre of Science & Innovation Vice-rector and Business Development, Semmelweis University, Budapest, Hungary
10: Heart and Vascular Center, Semmelweis University, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session I. - N: Health Sciences

Language of the presentation

English

Preferred session

Health Sciences

Összefoglaló szövege

Introduction: The relationship between biomarkers of bone remodeling due to regular exercise is not known, it is not possible to predict the optimal type and volume of exercise for bone remodeling. Aims: We aimed to quantify the effects of regular training on bone remodeling biomarkers, particularly osteocalcin and bone alkaline phosphatase in healthy adult populations.
Methods: This study (PROSPERO: CRD42023483811) explored the effects of regular training through a systematic review and meta-analysis and included only randomized controlled trials of different types (endurance, power, and mixed) and intensities, frequency and duration of training. MEDLINE, Embase, and CENTRAL were searched on November 22, 2023. Risk-of-bias and quality assessment were performed by Cochrane RoB2 and GradePro.
Results: A total of 12,828 records were screened, and 22 studies with 1,126 participants were analyzed. Endurance training showed no significant effect on osteocalcin level. High- and low-intensity endurance training also had no significant effect on osteocalcin. High-intensity interval training (HIIT) significantly increased osteocalcin levels (MD = 12.00; 95% CI: 8.40 to 15.50). Power training showed no significant change in osteocalcin levels. Mixed training (endurance + power) did not significantly change osteocalcin levels. Bone alkaline phosphatase showed no significant change following endurance training. Bone Mineral Density showed no significant changes after endurance and power training. Endurance training decreased the body mass index, but the result was not statistically significant. The risk of bias was low for all outcomes. Grade assessment for osteocalcin in the HIIT group revealed moderate to low certainty.
Conclusion: This is the first systematic review and meta-analysis on the effects of regular training on bone biomarkers in healthy adults to show that HIIT significantly increases bone remodeling as indicated by elevated osteocalcin, whereas other training types had no effect.
Funding: . Our findings highlight that when the synergistic effect of high intensity, dynamic loading, and rest periods during training were simultaneously present, we observed significant changes in bone metabolism markers and a strong positive trend in the improvement of body mass index and bone mineral density.

University

Semmelweis University

Supervisor

Péter Ferdinandy/Nóra Sydó

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8755

Start

16:30

End

16:36