PhD Scientific Days 2025

Poster Session III. - R: Neurosciences

Distinct Thalamo-Cortical Inputs Define Subnucleus-Specific Information Processing in the Amygdala

Előadó neve

Berki Peter

Neptun code

W83K4G

Előadó munkahelye

HUN-REN Institute of Experimental Medicine

Előadó telefonszáma

06306156522

Előadó e-mail címe

berki.koki@gmail.com

Az előadás címe

Distinct Thalamo-Cortical Inputs Define Subnucleus-Specific Information Processing in the Amygdala

Szerző(k) neve és munkahelye

Peter Berki¹, Ákos Babiczky², Kinga Kocsis³, Aletta Magyar¹, Sándor Borbély¹, Antal Berényi⁴, Ferenc Mátyás¹

1: HUN-REN Institute of Experimental Medicine
2: Netherlands Institute for Neuroscience
3: NYU Neuroscience Institute
4: University of Szeged

Bemutatás módja

Poszter

Szekció

Poster Session III. - R: Neurosciences

Language of the presentation

English

Preferred session

Neurosciences

Összefoglaló szövege

Emotional regulation is an important higher-order function of the nervous system, which plays a critical role in our daily life. During this process, external multisensory stimuli are integrated with internal (arousal, salience) signals, a mechanism essential for generating fast and adaptive behavioural responses across diverse situations. Importantly, pathological alterations of emotional regulation (e.g., mood disorders, depression, PTSD) impose substantial mental and financial burdens on our society, therefore, elucidating the underlying mechanisms behind these processes is of great importance. The amygdala is a known mediator of fear learning through computing external cues (threat) and internal (arousal-related) signals. However, fine details about these coding mechanisms remains unclear. While there is a widely known model which posits serial information processing of these signals from cortical and thalamic regions to cortical-like amygdala subnuclei (lateral and basolateral), generating an output in the central nuclei of the amygdala, evidence supporting this view is inconsistent. Recently gathered data indicate that different amygdala subnuclei receive inputs from distinct cortical and thalamic regions in a largely non-overlapping manner, and strongly suggests a more complex, subnucleus-specific parallel mode of processing. In order to reveal the exact information flow within distinct thalamic subnuclei, we carried out complex anatomical tracing experiments combined with human tractography and high-density electrophysiological recordings. We demonstrate that there is a dichotomy in the thalamo-cortico-amygdala network existing both in human and mice, which is composed of several parallel intra-amygdala routes with separate striatal outputs. Therefore, our results challenge the current view of emotional processing in the amygdala and suggests that different aspects of emotional behaviour are mediated by separate amygdala circuits.

University

Semmelweis University

Supervisor

Ferenc Mátyás

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4078

Start

15:06

End

15:12