PhD Scientific Days 2025

Poster Session I. - Y: Surgical Medicine

Comparison of the Effect of Preoperative Resistance and Endurance Exercise on Postoperative Outcomes in a Rat Model of High-risk Colon Anastomosis

Előadó neve

Dr. Kovacs Szabina

Neptun code

O0K9P1

Előadó munkahelye

Department of Surgery, Transplantation and Gastroenterology

Előadó telefonszáma

+36308540673

Előadó e-mail címe

kovacs.szabina@stud.semmelweis.hu

Az előadás címe

Comparison of the Effect of Preoperative Resistance and Endurance Exercise on Postoperative Outcomes in a Rat Model of High-risk Colon Anastomosis

Szerző(k) neve és munkahelye

Szabina Kovacs¹, Klara Levay¹, Ildiko Horvath², Noemi Kovacs², Domokos Mathe², Krisztian Szigeti², Balint Hofmeister³, Eszter Ostorhazy³, Andras Budai⁴, Attila Szijarto¹, Andras Fulop¹

1: Department of Surgery, Transplantation and Gastroenterology
2: Department of Biophysics and Radiation Biology
3: Institute of Medical Microbiology
4: Department of Pathology, Forensic and Insurance Medicine

Bemutatás módja

Poszter

Szekció

Poster Session I. - Y: Surgical Medicine

Language of the presentation

Hungarian

Preferred session

Surgical Medicine

Összefoglaló szövege

Prehabilitation is a preoperative program aiming to improve patients’ physical condition through exercise, nutrition and psychological support to overcome subsequent surgical stress. Prehabilitation is widely investigated in colorectal surgery, where the most feared complication is anastomotic leak, which has several modifiable preoperative risk factors potentially affected by exercise as the main element of prehabilitation. However, its effectiveness is controversial as the large heterogeneity of exercise protocols hampers comparative research. Distinct forms of exercise, like endurance or resistance training, induce different physiological responses, which may affect postoperative outcomes differently, thus, consensus is needed on the applied protocol.
We aimed to compare the effect of resistance and endurance training on anastomotic healing in a high-risk colon anastomosis model.
After 4 weeks of sedentary (S), endurance (E) and resistance (R) exercise based prehabilitation protocols male Wistar rats were divided into low (S, E, R) and high surgical risk (SC, EC, RC) groups depending on wether colitis (C) was induced or not prior to colon resection. Changes in exercise performance and body composition by magnetic resonance imaging were analyzed before surgery. Colitis activity was estimated by the Disease Activity Index (DAI) score. Postoperative vulnerability was measured by determining survival, weight loss and Rat Grimace Scale (RGS). Anastomotic leak and healing were assessed by adhesion score and anastomotic bursting pressure measurement.
Increased resistance exercise performance indicated improved muscle strength in the R and RC groups, enhanced aerobic training capacity suggested higher endurance in the E and EC groups compared to the other groups. The colitis activity was reduced in both the RC and EC groups, as shown by lower DAI than the SC group. Postoperative outcome improved in the RC but not in the EC group, indicated by increased survival, reduced body weight loss and lower RGS compared to the SC group. While anastomotic healing also ameliorated in the RC but not in the EC group showed by less adhesion and elevated bursting pressure compared to the SC group.
Resistance but not endurance training-based prehabilitation protocols improve anastomotic healing and promote postoperative recovery.
SE 250+ PhD Excellence Grant (123954/DIDIT/2024)

University

Semmelweis University

Supervisor

Andras Fulop

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8030

Start

16:30

End

16:36