PhD Scientific Days 2025

Poster Session I. - D: Pathological and Oncological Sciences

Prognostic Role of Stroma AReactive Invasion Front Areas in intestinal and non-intestinal type gastric adenocarcinomas

Előadó neve

Dr. Kocsmár Éva, PhD

Előadó munkahelye

Semmelweis University, Department of Pathology, Forensic and Insurance Medicine

Előadó telefonszáma

+36305819025

Előadó e-mail címe

evakocsmar9@gmail.com

Az előadás címe

Prognostic Role of Stroma AReactive Invasion Front Areas in intestinal and non-intestinal type gastric adenocarcinomas

Szerző(k) neve és munkahelye

Éva Kocsmár¹, Ákos Jakab¹, Luca Szalai², Bettina Zengő¹, Ildikó Kocsmár³, Tibor Várkonyi¹, István Kenessey⁴, Attila Szijártó⁵, András Kiss¹, Tamás Vass⁵, Gábor Lotz¹

1: Department of Pathology, Forensic and Insurance Medicine, Semmelweis University
2: Department of Pathology, National Institute of Oncology
3: Department of Urology, Semmelweis University
4: National Cancer Registry, National Institute of Oncology
5: Department of Surgery, Transplantation and Gastroenterology, Semmelweis University

Bemutatás módja

Poszter

Szekció

Poster Session I. - D: Pathological and Oncological Sciences

Language of the presentation

Hungarian

Preferred session

Pathological and Oncological Sciences

Összefoglaló szövege

Introduction: Gastric cancer (GC) is a major cause of death from malignancies worldwide. The aggressive nature of GC, late diagnosis and lack of reliable histological prognostic markers contribute to poor survival rates. Stroma AReactive Invasion Front Areas (SARIFA) is a newly identified histological feature characterized by a direct connection between tumor cells and adipocytes at the tumor invasion front.

Aims: This study aimed to evaluate the prognostic significance of SARIFA in GC.

Method: A retrospective analysis was performed on 333 GC patients. Cases were categorized as intestinal (n=171) and non-intestinal (n=162) according to Lauren's classification of histological type. SARIFA was assessed on H&E-stained digital slides at the invasion front, recording the presence (yes/no) and quantifying the number of foci where tumour cells directly contacted adipocytes. Tumour buds (TB) and poorly differentiated clusters (PDC) were evaluated according to the International Tumour Budding Consensus Conference.

Results: SARIFA+ status correlated with negative prognostic factors, including higher pT stage, incomplete resection margins, perineural invasion, lymph node metastases, and higher lymph node ratios in both intestinal and non-intestinal groups. Despite SARIFA's association with higher TB and PDC categories, the correlation between SARIFA foci and TB/PDC numbers was weak (intestinal: rho=0.29, rho=0.19; non-intestinal: rho=0.25, rho=0.25). Time-dependent ROC curves indicated that the optimal SARIFA cut-off for 5-year survival is the "present/absent" categorization. Univariate and multivariate COX regression analyses identified SARIFA+ as an independent negative prognostic factor for overall survival in non-intestinal GC (p=0.003; p=0.03).

Conclusion: SARIFA is a readily assessable histological marker that provides valuable prognostic information for GC. Further research is needed to integrate SARIFA into routine diagnostic practice.

Funding: Supported by the EKÖP-2024-72 New National Excellence Program of the Ministry For Culture And Innovation from the Source of the National Research, Development And Innovation Fund and the K_22 142604 grant of the National Research, Development and Innovation Office.

University

Semmelweis University

Supervisor

Dr. Éva Kocsmár

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

after finishing doctoral studies with absolutorium (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

2223

Start

16:36

End

16:42