PhD Scientific Days 2025

Cardiovascular Medicine and Research II.

Pulsed Field Ablation for Ventricular Arrhythmias With Pentaspline Catheter

Előadó neve

Dr. Padisák Anna

Neptun code

QZPLHP

Előadó munkahelye

Semmelweis University Heart and Vascular Center

Előadó telefonszáma

+36704299599

Előadó e-mail címe

annnaborbala@gmail.com

Az előadás címe

Pulsed Field Ablation for Ventricular Arrhythmias With Pentaspline Catheter

Szerző(k) neve és munkahelye

Anna Padisák¹, Nándor Szegedi¹, Edit Tanai¹, Zoltán Salló¹, Klaudia Vivien Nagy¹, Péter Perge¹, Márton Boga¹, Gábor Orbán¹, Patrik Tóth¹, Ferenc Komlósi¹, Béla Merkely¹, László Gellér¹

1: Semmelweis University Heart and Vascular Center

Bemutatás módja

Szóbeli

Szekció

Cardiovascular Medicine and Research II.

Language of the presentation

English

Preferred session

Cardiovascular Medicine and Research

Összefoglaló szövege

Introduction and Aims
Catheter ablation using pulsed-field energy may penetrate deeper into scarred tissue than thermal energies; however, evidence regarding its role in treating ventricular arrhythmias (VA) is limited. In this prospective study, we report our current experience on pulsed-field ablation (PFA) with pentaspline catheter for the treatment of premature ventricular contractions (PVC) originating from the right ventricular outflow tract (RVOT) and scar-related ventricular tachycardias (VT).

Methods
Consecutive VA patients who underwent PFA with Farapulse system were enrolled. Seven patients underwent ablation for idiopathic RVOT PVCs, and five patients with structural heart disease underwent ablation for scar-related VTs. The recurrence of arrhythmias was assessed by 24-hour Holter electrocardiography monitoring or implantable cardioverter defibrillator interrogation.

Results
Twelve patients were enrolled, age 51±9 years, 9 were men, 4 had previously failed radiofrequency ablation. Procedural and fluoroscopy times were 53 (41-105) minutes and 8 (4–20) minutes, respectively. The median number of PFA applications was 20±13 in the VT group and 8 (7-8) in the PVC group. Acute procedural success was achieved in 92% (CI 62-100%) of patients. During a mean follow-up of 100 (97-140) days, freedom from VT was 80% (CI 28-99%) and a PVC burden <1% was achieved in 71% (CI 29-96%) of patients.

Conclusions
The ablation of idiopathic RVOT PVCs and scar-related VTs with the pentaspline PFA catheter is feasible with good acute and mid-term efficacy observed in our cohort. Further research involving larger cohorts and longer follow-up periods is needed to analyse the safety and define the role of PFA in VAs.

FUNDING
M.B. and G.O. were supported by the EKÖP-2024-167 and EKÖP-2024-265, respectively, through the New National Excellence Program of the Ministry for Culture and Innovation, funded by the National Research, Development and Innovation Fund. G.O., M.B. and N.S. were supported by the MD-Ph.D. Excellence Program of Semmelweis University (EFOP-3.6.3-VEKOP-16-2017-00009). The scientific work/research and/or results publicised in this article were reached with the sponsorship of the Gedeon Richter Talentum Foundation in the framework of the Gedeon Richter Excellence Ph.D. Scholarship of Gedeon Richter.

University

Semmelweis University

Supervisor

Dr. Nándor Szegedi

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem hagyta jóvá

Előadó

8933

Start

15:45

End

16:00