PhD Scientific Days 2025

Dental Research

The Potential Role of the SIRT1 Protein in the Development of Medication-Related Osteonecrosis of the Jaw

Előadó neve

Mr. Bojtor Bence

Neptun code

FTJV6V

Előadó munkahelye

Department of Internal Medicine and Oncology, Semmelweis University

Előadó telefonszáma

+36204832828

Előadó e-mail címe

bojtorbence01@gmail.com

Az előadás címe

The Potential Role of the SIRT1 Protein in the Development of Medication-Related Osteonecrosis of the Jaw

Szerző(k) neve és munkahelye

Bence Bojtor¹, Szófia Szentpéteri², Mihály Vaszilkó², Péter Lakatos¹, János Kósa¹

1: Department of Internal Medicine and Oncology, Semmelweis University
2: Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University

Bemutatás módja

Szóbeli

Szekció

Dental Research

Language of the presentation

Hungarian

Preferred session

Dental Research

Összefoglaló szövege

Introduction
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse effect most commonly associated with bisphosphonates and the RANKL inhibitor denosumab in treating osteoporosis or tumor-related bone metastases. The pathomechanism of MRONJ is currently not fully understood. However, our previous research has suggested a potential role for the SIRT1 gene and protein in the development of the disease.

Aims
The primary aim of this study was to assess serum levels of the SIRT1 protein in patients with medication-related osteonecrosis of the jaw (MRONJ) compared to healthy controls. Additionally, we sought to explore the relationship between SIRT1 serum levels and clinical parameters, including disease severity, to further elucidate the potential role of SIRT1 in the pathogenesis of MRONJ.

Methods
The study included 23 patients with MRONJ and 8 healthy controls. Serum levels of SIRT1 were measured using the ELISA method. A non-parametric statistical test was used to compare the patient and control groups. Within the patient group, correlations between SIRT1 serum levels and clinical parameters were analyzed using correlation tests, and serum level differences between subgroups were assessed via analysis of variance.

Results
The average SIRT1 serum level in the MRONJ group was 3.078 ng/mL, compared to 4.86 ng/mL in the control group. The difference between the two groups was not statistically significant (p = 0.477). A significant negative correlation was observed between MRONJ stage and SIRT1 serum level, both when considering all patients (r = -0.566, p = 0.035) and when analyzing only those patients who expressed SIRT1 (r = -0.737, p = 0.0195).

Conclusions
Our results indicate a decreasing trend in SIRT1 protein serum levels with increasing severity of MRONJ. These findings further support the potential role of SIRT1 in the pathomechanism of MRONJ and may contribute to the foundation of a future predictive biomarker system.

Funding
This study was supported by the Egyetemi Kutatói Ösztöndíj Program (University Research Scholarship Program), grant number EKÖP-2024-34.

University

Semmelweis University

Supervisor

Péter Lakatos, János Kósa

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

jóváhagyta

Előadó

8936

Start

10:30

End

10:45