PhD Scientific Days 2025

Conservative Medicine I.

Investigating the Effects of Biological Therapies on the Cardiovascular Risk in Psoriasis

Előadó neve

Dr. Kolonics Mária Veronika

Neptun code

C0CJX4

Előadó munkahelye

Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Centre for Translational Medicine, Semmelweis University

Előadó telefonszáma

+36309776619

Előadó e-mail címe

mv.kolonics@gmail.com

Az előadás címe

Investigating the Effects of Biological Therapies on the Cardiovascular Risk in Psoriasis

Szerző(k) neve és munkahelye

Mária Veronika Kolonics MD¹, Noémi Ágnes Galajda MD¹, Katalin Martyin MD¹, Fanni Adél Meznerics MD PhD¹, Ákos Ungvári¹, Adib Abed², Anna Czibulya¹, Péter Kulyassa³, Máté Krebs¹, Dániel Sándor Veres MD PhD², Karen Fazekas PhD², András Bánvölgyi MD PhD¹, Prof. Péter Holló MD, PhD¹

1: Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Centre for Translational Medicine, Semmelweis University
2: Centre for Translational Medicine, Semmelweis University
3: Heart and Vascular Center, Semmelweis University, Centre for Translational Medicine, Semmelweis University

Bemutatás módja

Szóbeli

Szekció

Conservative Medicine I.

Language of the presentation

English

Preferred session

Conservative Medicine

Összefoglaló szövege

Introduction:
Cardiovascular diseases remain the leading cause of global mortality, driven by a combination of metabolic and inflammatory factors. Psoriasis, a chronic inflammatory disease, mainly affecting the skin, has been associated with elevated cardiovascular risk resulting in higher prevalence of major cardiovascular events, due to shared immune-mediated pathways and excessive systemic inflammation. While several studies report beneficial effects of anti-inflammatory biologicals on cardiovascular risk, comparative data remains inconclusive, and the most effective agent has yet to be identified.
Aims:
Our research aims to systematically review and synthesize existing literature on the cardiovascular effects of biological therapies in psoriasis, to identify which biological therapies reduce the incidence of cardiovascular events most effectively.
Methods:
The searches were conducted in three databases (PubMed, Embase, and Cochrane Library) to identify publications reporting major cardiovascular outcomes in psoriatic patients treated with biological therapies (TNF-alpha inhibitors, interleukin-12/23, interleukin-17, and interleukin-23 inhibitors).
Results:
The finalized search strategy yielded 14,932 hits, which were narrowed down to 3,153 records following the title and abstract selection. Data are currently being extracted from 325 full-text articles, including 142 studies on TNF-alpha inhibitors, 63 on interleukin-12/23 inhibitors, 107 on interleukin-17 inhibitors, and 89 on interleukin-23 inhibitors.
Conclusions:
Given the potential cardiovascular implications of psoriasis treatments, synthesizing the current evidence is critical for clarifying possible therapeutic benefits, supporting evidence-based clinical decision-making.
Funding: the presenter is a recipient of the Semmelweis 250+ Scholarship for Excellence.

University

Semmelweis University

Supervisor

Prof. Péter Holló MD PhD, András Bánvölgyi MD PhD

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem hagyta jóvá

Előadó

7995

Start

11:30

End

11:45