PhD Scientific Days 2025

Poster Session III. - V: Cardiovascular Medicine and Research

Temporal changes in serpinA3 and periostin levels during transcatheter aortic valve replacement

Előadó neve

Dr. Bálint Tímea

Neptun code

SQDMXM

Előadó munkahelye

Semmelweis University Heart and Vascular Center, Budapest, Hungary

Előadó telefonszáma

+36203362368

Előadó e-mail címe

balint.timea09@gmail.com

Az előadás címe

Temporal changes in serpinA3 and periostin levels during transcatheter aortic valve replacement

Szerző(k) neve és munkahelye

Tímea Bálint¹, Dávid Nagy¹, Zsuzsanna Ladányi¹, Bálint Károly Lakatos¹, Petra Kocsis-Balogh¹, Zoltán Horváth¹, Bálint András Barta¹, Attila Oláh¹, Alex Ali Sayour¹, Éva Straub¹, Endre Zima¹, Levente Molnár¹, Béla Merkely¹, Tamás Radovits¹, Mihály Ruppert¹

1: Semmelweis University Heart and Vascular Center, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session III. - V: Cardiovascular Medicine and Research

Language of the presentation

Hungarian

Preferred session

Cardiovascular Medicine and Research

Összefoglaló szövege

Introduction: Emerging evidence suggests that cardiac diseases, including aortic stenosis (AS), may contribute to cancer development via chronic inflammation, oxidative stress, and pro-fibrotic signalling. Proteins such as serpinA3 and periostin have been implicated in both pressure overload-induced heart failure and cancer progression. It is hypothesized that these proteins, released from the remodelled myocardium, may foster a tumour-promoting microenvironment. This study explores whether reverse remodelling after transcatheter aortic valve replacement (TAVR) affects their circulating levels.
Aims: This study aimed to investigate the dynamic changes in circulating serpinA3 and periostin levels in patients with AS undergoing TAVR.
Methods: Twenty-one patients (age: 81±1 years, 52% female) with severe AS underwent TAVR. Echocardiographic assessments and blood samples were obtained at three time points: within 24 hours preoperatively (preop), within 24 hours postoperatively (postop), and at the six-month follow-up (6MFU). Serum serpinA3 and periostin levels were measured using ELISA. NT-proBNP levels were assessed preoperatively and at 6MFU as part of routine clinical laboratory testing.
Results: Baseline left ventricular (LV) ejection fraction was 55±4%. At 6MFU, significant reverse remodelling was observed, including reduced global work index (2395±150 vs. 1947±117 mmHg%, p<0.05) and LV end-diastolic diameter (50.4±2 vs. 44.9±1 mm, p<0.05). NT-proBNP levels tended to decrease (2304±552 vs. 993±146 pg/mL, p=0.057). SerpinA3 levels rose significantly after TAVR (262.6±27 to 457.7±50 µg/mL, p<0.001), then declined at 6MFU (457.7±50 to 291±50 µg/mL, p<0.001), yet remained above baseline. Periostin levels were unchanged postoperatively (104.7±6 vs. 100.4±8 ng/mL, p=0.06) but significantly increased at 6MFU (100.4±8 to 128.5±11 ng/mL, p<0.001).
Conclusion: Contrary to expectations, reverse remodelling induced by TAVI in patients with AS was not associated with a reduction in circulating serpinA3 and periostin levels.
Funding: EKÖP-2024-213 (T.B.), STARTING 150923 (M.R.)
balint.timea09@gmail.com
Semmelweis University,
Supervisors: Mihály Ruppert, MD, PhD and Prof. Tamás Radovits, MD, PhD

University

Semmelweis University

Supervisor

Mihály Ruppert, MD, PhD and Prof. Tamás Radovits, MD, PhD

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7470

Start

14:30

End

14:36