PhD Scientific Days 2025
Budapest, 7-9 July 2025
Neurosciences
Superior collicular inhibitory effect on thalamic cells during fast, multisensory information processes
Előadó neve
Bakacsi Anna Virág, MSc
Neptun code
LNY56Y
Előadó munkahelye
HUN-REN Institute of Experimental Medicine
Előadó telefonszáma
+36/70-366-9794
Előadó e-mail címe
bakacs.anna@gmail.com
Az előadás címe
Superior collicular inhibitory effect on thalamic cells during fast, multisensory information processes
Szerző(k) neve és munkahelye
Anna Virág Bakacsi1,2, Anett Futácsi3, Gergely Szarka3, Péter Berki1,2, Aletta Magyar1,2, Sándor Borbély1, Kinga Kocsis4, Béla Völgyi3, Ferenc Mátyás1,5
1: Neuronal Network and Behavior Research Group, HUN-REN Institute of Experimental Medicine/ HUN-REN Research Centre for Natural Sciences, Budapest, Hungary
2: Semmelweis University Doctoral School, Budapest, Hungary
3: University of Pécs, Szentágothai Research Centre, Pécs, Hungary
4: NYU Langone Medical Center, New York City, United States
5: Department of Anatomy and Histology, University of Veterinary Medicine, Budapest, Hungary
Bemutatás módja
Szóbeli
Szekció
Neurosciences
Language of the presentation
English
Preferred session
Neurosciences
Összefoglaló szövege
In a constantly changing environment filled with information from multiple senses, the brain must quickly identify and combine important signals to guide appropriate behavior. Our previous work suggested that during threat learning, the association between conditioned and unconditioned stimuli could occur at the level of the amygdala-projecting calretinin-expressing lateral thalamic cells (LTCR), that receive strong superior collicular (SC) input (Barsy, Kocsis et al., 2020). SC is a key site for multisensory integration and has recently been implicated in higher cognitive functions, such as fear learning. However, the nature of the signals transferred and the SC-LTCR circuit’s role in fear processes remain largely unknown. To answer these questions, first, we anatomically dissected the SC-LTCR connection and found that not only the glutamatergic, but also the GABAergic SC cells were able to form synaptic contact with LTCR neurons. Our monosynaptic retrograde tracing also revealed that these cells carry distinct types of information to LTCR. Then, using optogenetics and electrophysiological approaches we examined the response properties of these LT-projecting SC cells to uni- and multimodal sensory stimuli in vGAT-Cre mice. We found that multisensory signals rather than the single sensory cues were able to alter the activity pattern of vGAT+ SC cells, which, in turn, modulated the LTCR cells with short latency. These latencies were consistent with the CS-US association window observed in the LT and amygdala (AMY). In sum, the SC-LTCR-AMY circuit mechanism can contribute to the fast and plastic signal integration during affective processes and promote the survival of the animal.
This work was supported by the Hungarian Scientific Research Fund NKFIH-FK 135285 (SB), FK144583 (SB), K138836 (FM) and KKP126998 (FM); by the ÚNKP-22-2-III-ELTE-539 (AVB), EKÖP-2024-276 (AVB) and EKÖP-2024-87 (PB) New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Found; by ELKH SA-48/2021 (FM); by the Cooperative Doctoral Programme (KD2020) to (AM); by the NKFI and the European Union under the action of the ERA-NET COFUND 2019-2.1.7-ERANET-2021–00018; NEURON (NEURON-066 Rethealthsi) to (BV) and the EKÖP-24-4-I-PTE-11 (GS) New National Excellence Program of the Ministry of Human Capacities.
University
Semmelweis University
Supervisor
Dr. Ferenc Mátyás and Dr. Sándor Borbély
Publication of my abstract
I do not give consent to the publication of my abstract on the website of the congress.
phd.section.field
in doctoral studies before complex exam (PhD)
Kind
Szabad
Status
elfogadva
Accepted presentation method
szóbeli
Előadás fájl jóváhagyás
nem hagyta jóvá
Előadó
8007
Start
09:15
End
09:30