PhD Scientific Days 2025

Poster Session III. - M: Mental Health Sciences

Genetic Variants of CCL11, CLDN5, and IL-6 genes in Depression

Előadó neve

Ms. Torok Dora

Neptun code

NXSU2H

Előadó munkahelye

Department of Pharmacodynamics

Előadó telefonszáma

+36705695093

Előadó e-mail címe

torok.dora01@gmail.com

Az előadás címe

Genetic Variants of CCL11, CLDN5, and IL-6 genes in Depression

Szerző(k) neve és munkahelye

Dora Torok¹, Karoly Hegedus¹, Zsofia Gal¹, Xenia Gonda¹, Gabriella Juhasz¹, Gyorgy Bagdy¹, Peter Petschner¹

1: Department of Pharmacodynamics

Bemutatás módja

Poszter

Szekció

Poster Session III. - M: Mental Health Sciences

Language of the presentation

English

Preferred session

Mental Health Sciences

Összefoglaló szövege

Elevated levels of certain chemokines in the central nervous system (CNS) have been linked to depression, yet their entry into the CNS remains unclear. One possible mechanism is inflammation and the compromised integrity of the blood-brain barrier (BBB). Previous research [1] revealed that single-nucleotide polymorphisms (SNPs) of Interleukin-6 (IL-6) and Claudin-5 (CLDN5) interact with stress in increasing depression risk. While a functional SNP in CLDN5 alone does not appear to increase susceptibility, its effect may become significant when combined with stress and the IL-6 variant. Research indicates that cytokines and chemokines could have a role in depression [2]; however, the precise mechanism by which these signaling molecules access the CNS and cause depression remains unclear. Investigating this link between stress, inflammation, and the integrity of the BBB is particularly important.

Based on these, our objective was to test the hypothesis that functional SNP of the C-C motif chemokine 11 coding gene interacts with previously identified CLDN5 and IL-6 variants in depression, and that stress further modulates this interaction.

We used genetic and phenotypic data from the UK Biobank (N = 334,125). We selected rs1860184 from the CCL11 gene [3], and we tested the two SNPs identified in our previous study [1]. As a depression phenotype, we used depression diagnosis and experienced recent life stress exposures. We performed interaction analyses using R (version 4.1.2).

Three-way interaction analysis between rs1860184 - CCL11 and rs1800795 – IL6 and rs885985 – CLDN5 did not show significant interaction effect (p-value 0.760, OR = 0.0397 (SE = 0.9139)). Regarding the effect of recent stress, four-way interaction did not show significant results (p-value 0.6784, OR = 0.8892 (SE = 1.0793)).

These negative findings indicate that the interaction of genetic variants of CCL11, IL-6, CLDN5, and the modifying effect of recent stress remains uncertain. Although the current study did not yield statistically significant interaction effects, these findings are crucial for refining existing models of depression pathophysiology. Future research should consider incorporating polygenic risk scores (PRS) that aggregate effects across multiple loci to provide a more comprehensive assessment of genetic risk.

KTIA_NAP_13-2- 2015-0001, EKÖP-2024-68.

University

Semmelweis University

Supervisor

Peter Petschner, Gabriella Juhasz

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7397

Start

14:06

End

14:12