PhD Scientific Days 2025

Pharmaceutical Sciences and Health Technologies I.

Bioavailibility Enhancement of Kratom Alkaloids by Cyclodextrin Complexation

Előadó neve

Dr. Dohárszky András

Neptun code

JQKX56

Előadó munkahelye

Department of Pharmacognosy, Semmelweis University, Budapest, Hungary

Előadó telefonszáma

+36308502773

Előadó e-mail címe

andras.doharszky@gmail.com

Az előadás címe

Bioavailibility Enhancement of Kratom Alkaloids by Cyclodextrin Complexation

Szerző(k) neve és munkahelye

András Dohárszky¹, Ida Fejős¹

1: Department of Pharmacognosy, Semmelweis University, Budapest, Hungary

Bemutatás módja

Szóbeli

Szekció

Pharmaceutical Sciences and Health Technologies I.

Language of the presentation

English

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction
Kratom (Mitragyna speciosa) leaves have been traditionally used in Southeast Asia for their analgesic, wound-healing, and stimulant effects. These pharmacological properties are primarily attributed to mitragynine and its related alkaloids, which, despite their therapeutic potential, suffer from poor water solubility and low chemical stability.
Aims
This study aimed to identify the most suitable cyclodextrin (CD) derivatives for forming stable inclusion complexes with kratom alkaloids to enhance their aqueous solubility and stability.
Methods
An affinity capillary electrophoresis (ACE) method was developed to systematically investigate the complexation of mitragynine, speciociliatine, speciogynine, and paynantheine with nearly 40 CD derivatives. The promising CDs were selected for phase-solubility studies.
Results
Our ACE and phase-solubility study results revealed that medium-cavity-size β-CD derivatives proved to be promising complexing agents. The negatively charged sugammadex, subetadex, and the sufoalkylated-beta-CD analogs formed the most stable inclusion complexes, and the solubility of mitragynine.
Conclusion
The CD complexation results of these promising secondary plant metabolites presented here provide a strong foundation for future pharmaceutical development focused on improving the solubility and bioavailability of various kratom alkaloids.
Funding
Funded by SE 250+ Excellence PhD Scholarship

University

Semmelweis University

Supervisor

Ida Fejős PhD

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem hagyta jóvá

Előadó

9024

Start

15:15

End

15:30