PhD Scientific Days 2025

Poster Session I. - F: Pharmaceutical Sciences and Health Technologies

Study on Lyophilised Orodispersible Tablets from Plant-Based Drinks as Bulking Agents

Előadó neve

Dr. Demeter Adrienn Katalin

Neptun code

PGMEP3

Előadó munkahelye

Semmelweis University

Előadó telefonszáma

+36307424219

Előadó e-mail címe

demeter.adrienn.katalin@semmelweis.hu

Az előadás címe

Study on Lyophilised Orodispersible Tablets from Plant-Based Drinks as Bulking Agents

Szerző(k) neve és munkahelye

Adrienn Katalin Demeter¹, Dóra Farkas¹, Márton Király¹, Zoltán Kovács², Krisztina Ludányi¹, István Antal¹, Nikolett Kállai-Szabó¹

1: Semmelweis University
2: Hungarian University of Agriculture and Life Sciences

Bemutatás módja

Poszter

Szekció

Poster Session I. - F: Pharmaceutical Sciences and Health Technologies

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Background/Objectives: Oral administration of active pharmaceutical ingredients (APIs) is the most commonly used route of administration. As dysphagia is a prevalent problem, the size of the swallowed dosage form could negatively influence patient adherence. Orally disintegrating tablets (ODTs) are beneficial dosage forms because they disintegrate within a few seconds in the oral cavity without water. Lactose is one of the most commonly used excipients in the pharmaceutical industry; it served as the central concept of a recent publication on the formulation of milk-based ODTs despite lactose malabsorption being widespread worldwide. Consequently, the plant-based alternative market has grown exponentially and has become a prevailing food trend, with various alternatives to choose from. For this reason, the development of a non-steroidal anti-inflammatory drug (NSAID)-containing ODT with plant-based drinks (PBDs) was assessed for its innovative potential.
Methods: Different PBDs were investigated and compared to traditional and lactose-free milk. The liquids’ viscosity, pH, and particle size were determined, and an electronic tongue was used for the sensory evaluation. The various ODTs were prepared with the freeze-drying method, and then the qualitative characteristics of the dosage form were investigated.
Results: Our different measurements show that different plant beverages differ from each other and that these differences have an impact on the technological processing. According to the HPLC-DAD measurements, all values were in the required range.
Conclusions: These measurements suggest that the soya drink is the most similar to traditional cow milk and would be the most appropriate choice among the investigated plant-based drinks to be used as a carrier system for an ibuprofen-containing ODT.

University

Semmelweis University

Supervisor

Nikolett Kállai-Szabó

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7981

Start

17:24

End

17:30