PhD Scientific Days 2025

Theoretical and Translational Medicine I.

Fabrication, Degradation Dynamics and Mechanical Integrity of Advanced Composite Electrospun Meshes

Előadó neve

Mr. Manikion Kenigen

Neptun code

L3ZZ27

Előadó munkahelye

Semmelweis University

Előadó telefonszáma

+36703948480

Előadó e-mail címe

kenigen.manikion33@gmail.com

Az előadás címe

Fabrication, Degradation Dynamics and Mechanical Integrity of Advanced Composite Electrospun Meshes

Szerző(k) neve és munkahelye

Kenigen Manikion¹

1: Semmelweis University

Bemutatás módja

Szóbeli

Szekció

Theoretical and Translational Medicine I.

Language of the presentation

English

Preferred session

Theoretical and Translational Medicine

Összefoglaló szövege

Introduction:
Achieving successful tissue integration remains a major challenge in regenerative medicine. Insufficient cell adhesion, infiltration, and migration within implanted biomaterials can trigger immune responses, leading to fibrous capsule formation and eventual implant isolation. To overcome these limitations, attention has turned to composite and blended materials. Polymers like polycaprolactone (PCL) and polylactic acid (PLA) are widely used in biomedical fields due to their biocompatibility, chemical stability, and affordability. However, their drawbacks include hydrophobicity, limited cell adhesion, and slow degradation. Polysuccinimide (PSI), on the other hand, is a promising biopolymer known for its excellent biocompatibility, rapid biodegradation, and strong support for cell attachment. Combining PSI with PCL or PLA may yield materials better suited for tissue integration.

Objectives:
This study aimed to develop electrospun fiber meshes using various combinations of PCL/PSI and PLA/PSI.

Materials and Methods:
We fabricated blend-electrospun meshes using PSI with PLA and PCL polymers. These meshes underwent comprehensive chemical, physical, and mechanical characterization.

Results:
Scanning electron microscopy confirmed uniform mesh structures without defects. ATR-FTIR analysis verified the presence of both polymers in the blends. The average fiber diameter was 650 nm for PSI/PLA meshes and 600 nm for PSI/PCL meshes. The specific loading capacities were 0.061 Nm²/g for PSI/PLA and 0.250 Nm²/g for PSI/PCL. Both mesh types degraded over time, showing a corresponding decline in tensile strength as degradation progressed.

Conclusion:
The PSI/PLA and PSI/PCL blend-electrospun meshes demonstrated structural consistency and a controlled degradation profile, supporting their suitability for tissue integration. PSI/PCL meshes offered greater mechanical strength compared to PSI/PLA, highlighting their potential for future use in regenerative medicine.

University

Semmelweis University

Supervisor

Dr. Voniatis Konstantinos

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

before finishing undergraduate studies (TDK, MD-PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

jóváhagyta

Előadó

8104

Start

09:30

End

09:45