PhD Scientific Days 2025
Budapest, 7-9 July 2025
Poster Session I. - F: Pharmaceutical Sciences and Health Technologies
Reformulating boswellic acids: a cyclodextrin-based approach for improved solubility and bioavailability
Előadó neve
Stifter-Mursits Marcell, MSc
Neptun code
OGN891
Előadó munkahelye
Department of Pharmaceutical Chemistry - Semmelweis University
Előadó telefonszáma
+36303223023
Előadó e-mail címe
stifter.marcell@phd.semmelweis.hu
Az előadás címe
Reformulating boswellic acids: a cyclodextrin-based approach for improved solubility and bioavailability
Szerző(k) neve és munkahelye
Marcell Stifter-Mursits1, Anna Vincze1, Réka E. Angi1, György T. Balogh1,2, Péter Püski3, Tivadar Kiss3, Attila Hunyadi3,4
1: Department of Pharmaceutical Chemistry - Semmelweis University
2: Center for Pharmacology and Drug Research & Development - Semmelweis University
3: Institute of Pharmacognosy - University of Szeged
4: HUN-REN-SZTE Biologically Active Natural Products Research Group - Szeged
Bemutatás módja
Poszter
Szekció
Poster Session I. - F: Pharmaceutical Sciences and Health Technologies
Language of the presentation
English
Preferred session
Pharmaceutical Sciences and Health Technologies
Összefoglaló szövege
Introduction:
Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides derived from starch, known for their ability to form inclusion complexes with lipophilic compounds. These complexes may result in increased solubility, stability and bioavailability of the guest molecules. Boswellic acids (BAs) are compounds with potential therapeutic applications in treating inflammatory diseases, but their use is limited due to their poor aqueous solubility (less than 1 µg/mL) and suboptimal pharmacokinetics.
Aims:
Our study focused on investigating the interaction of CDs with a series of BAs isolated from the resin of Boswellia Serrata Roxb. to overcome the associated limiting properties.
Methods:
The feasibility screening included various types of CDs differing in cavity size and charge. Phase solubility studies were conducted to select the best candidate for the solubilization of the four main components in the extract. Finally, the effective permeation of the extract was established in vitro using the parallel artificial membrane permeation assay (PAMPA).
Results:
The results generally indicated that CDs with larger cavity size and neutral charge show better interaction with BAs. Randomly-methylated-gamma-CD (RAMEG) at 5 w/v% was able to increase the solubility of BAs by well over 100-fold. However, based on the PAMPA studies, hydroxypropyl-gamma-CD (HPGCD) was able to facilitate the membrane permeation of BAs more effectively.
Conclusions:
The results highlight the potential of CDs to create formulations of therapeutic agents that were previously overlooked due to poor pharmacokinetics. Our further plans include developing preformulations of BAs for various administration routes to be tested in vivo for the treatment of metritis in cattle.
Funding:
The Boswellia Serrata Roxb. extracts were received from the Institute of Pharmacognosy, University of Szeged. The cyclodextrins used in the study were kind gifts of CycloLab Ltd.
stifter.marcell@phd.semmelweis.hu – POSTER presentation
Semmelweis University – Department of Pharmaceutical Chemistry
Prof. Balogh György Tibor
University
Semmelweis University
Supervisor
György Tibor Balogh
Publication of my abstract
I do not give consent to the publication of my abstract on the website of the congress.
phd.section.field
in doctoral studies before complex exam (PhD)
Kind
Szabad
Status
elfogadva
Accepted presentation method
poszter
Előadás fájl jóváhagyás
nem rendelkezett róla
Előadó
9076
Start
17:30
End
17:36