PhD Scientific Days 2025

Poster Session III. - S: Dental Research

Oral microbiom and colorectal cancer

Előadó neve

Ms. Bognár Katalin

Neptun code

BOF02I

Előadó munkahelye

Semmelweis University

Előadó telefonszáma

+36/304899375

Előadó e-mail címe

bkata20@gmail.com

Az előadás címe

Oral microbiom and colorectal cancer

Szerző(k) neve és munkahelye

Katalin Bognár¹

1: Semmelweis University

Bemutatás módja

Poszter

Szekció

Poster Session III. - S: Dental Research

Language of the presentation

Hungarian

Preferred session

Dental Research

Összefoglaló szövege

Introduction: Following the gastrointestinal tract, the oral cavity is the second most diverse and complex microbial community in the human body. Previous studies have linked the development of CRC to oral dysbiosis. They suggest that Fusobacterium nucleatum (Fn) is enriched in CRC tumor cells. Moreover, Fn may play a role in the development and progression of CRC and contribute to chemoresistance.
Aims: We aim to investigate the relative abundance of Fn in the saliva of colorectal cancer (CRC) patients and healthy controls. Depending on patients' oral health status, we offer further dental care in the Clinic for Oral Diagnostics (Faculty of Dentistry).
Method: We collect saliva at the Department of Surgery, Transplantation and Gastroenterology (Semmelweis University). We joined in the prehabilitation program, which prepares patients for surgery, (physically and mentally) and rehabilitation. We integrated in the prehabilitation oral examination, stomato-oncological screening, subjective periodontal questionnaire, and collection of unstimulated saliva. During our research, we examine patients' oral health and offer further professional dental care, if necessary. In the future, we will compare the amount of Fn DNA in saliva samples from CRC patients and control individuals.
Results: N= 80 (N=72 CRC group and N=8 control group) individuals have been tested. The results of the subjective questionnaire and the dental examination differ among the patients. In the questionnaire, only 36% of the patients (26 individuals) admitted to having inflamed gums, whereas in the oral examination, gingivitis was found in 71 % (47 individuals). Tooth mobility was reported by 8 patients (13%), while 14 patients (21%) were found to have mobility during oral examination. During stomato-oncological screening, potential precancerous lesions were suspected in 5 patients (7%).
Conclusion: In conclusion, we think that oral health and prevention is crucial for CRC patients before surgery.
Funding: 2024-2.1.1-EKÖP-2024-00004 Scholarschip

University

Semmelweis University

Supervisor

Dr. Ákos Zsembery, Dr. Anita Beck

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

before finishing undergraduate studies (TDK, MD-PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9067

Start

14:36

End

14:42