PhD Scientific Days 2025

Poster Session III. - R: Neurosciences

Function of the median raphe in the regulation of hippocampus

Előadó neve

Mr. Zsoldos Tamás

Neptun code

SF3F1E

Előadó munkahelye

Institute of Experimental Medicine

Előadó telefonszáma

+36305836993

Előadó e-mail címe

zsoldos.tamas@stud.semmelweis.hu

Az előadás címe

Function of the median raphe in the regulation of hippocampus

Szerző(k) neve és munkahelye

Zsoldos Tamás¹, Orosz Áron¹

1: Institute of Experimental Medicine

Bemutatás módja

Poszter

Szekció

Poster Session III. - R: Neurosciences

Language of the presentation

Hungarian

Preferred session

Neurosciences

Összefoglaló szövege

Introduction:
The median raphe region (MRR) is an important mood regulatory center of the brainstem. However, the function of the MRR vesicular glutamate transporter 3 (vGluT3) positive cells is poorly understood. Since their activity is enhanced by negative experiences, we hypothesized that their projection pathways contribute to the processing of negative experiences.
Objective:
In this work, we aim to map these pathways and understand their functions.
Methods:
We mapped the target-selective connections of MRR vGluT3 neurons using adeno-associated viral (AAV) fluorescent pathway tracing, and investigated their function using AAVs encoding photosensitive opsins and optogenetic methods. Histological processing was complemented by immunohistochemical techniques.
Results:
Our results showed that MRR vGluT3 neurons in the stratum lacunosum of the cornu ammonis regions of HIPP and in the hilus of the gyrus dentatus mainly innervate interneurons containing neuropeptide Y and calbindin. Our behavioural experiments suggest that these cells may play a role in linking events that do not overlap in time.
Conclusions:
Our results contribute to our understanding of the role of brainstem networks in the processing of negative experiences, which may also help to identify potential therapeutic targets.
Funding:
Project financed from the NRDI Fund, EKÖP-SE-2024.

Email adress: zsoldos.tamas@stud.semmelweis.hu
University: Semmelweis University
Supervisor: Dr. Nyiri Gábor

University

Semmelweis University

Supervisor

Dr. Nyiri Gábor

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

before finishing undergraduate studies (TDK, MD-PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9050

Start

14:06

End

14:12