PhD Scientific Days 2025

Poster Session III. - H: Pharmaceutical Sciences and Health Technologies

Formulation of Innovative Nanofibrous Patches for the Local Treatment of Oral Mucosal Lesions

Előadó neve

Dr. Nochta-Kazsoki Adrienn Katalin

Neptun code

R5CDJV

Előadó munkahelye

University Pharmacy Department of Pharmacy Administration, Semmelweis Univeristy, Budapest, Hungary

Előadó telefonszáma

+36302060093

Előadó e-mail címe

kazsoki.adrienn@semmelweis.hu

Az előadás címe

Formulation of Innovative Nanofibrous Patches for the Local Treatment of Oral Mucosal Lesions

Szerző(k) neve és munkahelye

Adrienn Katalin Nochta-Kazsoki¹, Houssam Abboud¹, Romána Zelkó¹

1: University Pharmacy Department of Pharmacy Administration, Semmelweis Univeristy, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session III. - H: Pharmaceutical Sciences and Health Technologies

Language of the presentation

English

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction: Oral lichen planus and recurrent aphthous ulcers are painful inflammatory conditions that significantly impact quality of life. Current treatments, such as mouth rinses and gels, offer limited efficacy due to poor adhesion and rapid clearance from the mucosa. Electrospun nanofiber patches present a promising alternative, enabling targeted and prolonged drug delivery.
Aims: This research aims to develop a multifunctional nanofiber patch incorporating steroids (anti-inflammatory), dexpanthenol (wound healing), and lidocaine (pain relief). Additionally, the project aims to comprehensively characterize the morphology and solid-state properties of the developed nanofibrous samples.
Method: The fibrous samples were fabricated via electrospinning from polyvinyl alcohol (PVA)-poloxamer 407 blends combined with either chitosan or hydroxypropyl methylcellulose (HPMC). Precursor solutions were optimized using two polymer ratios (9:0:1 and 7:2:1) to ensure fiber formation and desirable mucoadhesive properties. The resulting nanofibers were characterized using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). The critical precursor solution, process, and formulation parameters were investigated. The electrospun samples were characterized morphologically by scanning electron microscopy (SEM), and solid-state characterization was carried out by Fourier transform infrared spectroscopy.
Results: Successful fiber formation was obtained after optimizing the precursor solutions. SEM analysis confirmed uniform fiber morphology, while FT-IR and XRD data revealed the formation of amorphous solid dispersions for all active ingredients. The polymer blends created an effective platform for the local treatment of oral inflammatory lesions.
Conclusions: The developed multifunctional nanofibrous patch can enhance therapeutic outcomes by reducing inflammation and pain while promoting tissue regeneration. Fibrous webs are produced using a continuous, cost-effective, and highly controllable technology that can be integrated into modern pharmaceutical manufacturing.
Funding: This project was supported by the EKÖP-2024-181 New National Excellence Program of the Ministry for Culture and Innovation from The Source of the National Research, Development and Innovation Fund.

University

Semmelweis University

Supervisor

Adrienn Nochta-Kazsoki

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

after finishing doctoral studies with absolutorium (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8016

Start

15:18

End

15:24