PhD Scientific Days 2025

Poster Session II. - O: Health Sciences

Psychometric Testing of the ICECAP-A in Patients with Coeliac Disease: a Comparative Analysis with EQ-5D-5L

Előadó neve

Angyal Maria Mercédesz, MSc

Neptun code

G3T5LM

Előadó munkahelye

Semmelweis University

Előadó telefonszáma

+36305797708

Előadó e-mail címe

angyalmercedesz@gmail.com

Az előadás címe

Psychometric Testing of the ICECAP-A in Patients with Coeliac Disease: a Comparative Analysis with EQ-5D-5L

Szerző(k) neve és munkahelye

M. Mercédesz Angyal 1,2¹, Peter L. Lakatos 3,4², Valentin Brodszky 2³, Fanni Rencz 2³

1: 1-Károly Rácz Doctoral School of Clinical Medicine, Semmelweis University, Budapest, Hungary, 2-Department of Health Policy, Corvinus University of Budapest, Budapest, Hungary, 3- McGill University Health Centre
2: 3- McGill University Health Centre, Montreal General Hospital, Canada, 4- Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary
3: Department of Health Policy, Corvinus University of Budapest, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session II. - O: Health Sciences

Language of the presentation

Hungarian

Preferred session

Health Sciences

Összefoglaló szövege

Introduction: Coeliac disease (CD) is a food-related autoimmune condition that primarily affects the small intestine, with a global prevalence of 1%. Due to various symptoms and the strict gluten-free diet (GFD), the deterioration in patients’ health-related quality of life (HRQoL) is well-documented.

Aim: This study aims to assess the psychometric properties of the ICEpop CAPability measure for Adults (ICECAP-A) in patients with CD and compare its performance with the EQ-5D-5L.

Methods: An online cross-sectional survey was conducted among 312 adult CD patients in Hungary, who completed both the ICECAP-A and EQ-5D-5L. The following psychometric properties were assessed: ceiling, convergent validity with the Gastrointestinal Symptom Rating Scale (GSRS) and Satisfaction with Life Scale (SWLS) and known group validity. Mean ICECAP-A and EQ-5D-5L index values were computed using the Hungarian value sets [1,2]. To allow for comparison with the Hungarian population norms [3-4], ICECAP-A index values were also calculated using the UK value set [5], as this was used in the Hungarian population norm study.

results: Mean age was 36 years (range 18-80), and 70% were female. On the ICECAP-A, 51% (attachment) to 81% (stability) reported limitations in their capabilities. In comparison, 2% (self-care) to 41% (pain/discomfort) of patients reported problems on the EQ-5D-5L. No ceiling effect was observed on the ICECAP-A (7%), in contrast with a high ceiling effect on the EQ-5D-5L (39%). Mean index values of ICECAP-A were lower than the EQ-5D-5L (0.85 vs. 0.92). ICECAP-A correlated strongly with SWLS (rs=0.685), moderately with EQ-5D-5L (rs=0.485) and weakly with GSRS (rs=-0.314). The ICECAP-A differentiated between known groups by general health status and symptoms with large effect sizes (0.189-0.379). More limitations were reported among CD patients in multiple ICECAP-A items than the general population, particularly in stability (81% vs. 48%) and achievement (78% vs. 57%). Patients reported worse capability well-being across almost all age groups compared to the general population (mean ICECAP-A index: 0.76-0.86 vs. 0.84-0.92).

Conclusion: This is the first study to validate the ICECAP-A in patients with CD. The ICECAP-A is a valid measure in this population, sensitive to specific symptoms and health status.

University

Semmelweis University

Other university, not listed above

Funding sources: F.R.’s work was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00304/21) and the New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (ÚNKP-23-5-CORVINUS-5). Project no. 2023- 2.1.2-KDP-2023-00016 has been implemented with the support provided by the Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund, financed under the KDP-2023 funding scheme for M.M.A.’s work.

Supervisor

Prof. Dr. Rencz Fanni

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7469

Start

18:36

End

18:42