PhD Scientific Days 2025

Surgical Medicine

Comparison of Photon Counting Detector CT-based Renal Volumetry and Iodine Maps Versus Renal Scintigraphy for Predicting Remaining Kidney Function in Living Kidney Donor Candidates

Előadó neve

Dr. Csákai-Szőke Péter

Neptun code

D5E3V3

Előadó munkahelye

Medical Imaging Centre

Előadó telefonszáma

+36305437318

Előadó e-mail címe

csakaiszokepeter@gmail.com

Az előadás címe

Comparison of Photon Counting Detector CT-based Renal Volumetry and Iodine Maps Versus Renal Scintigraphy for Predicting Remaining Kidney Function in Living Kidney Donor Candidates

Szerző(k) neve és munkahelye

Dr. Csákai-Szőke Péter¹, Dr. Lénárd Zsuzsanna¹, Dr. Budai Bettina¹, Dakhlaoui Hana¹

1: Medical Imaging Centre

Bemutatás módja

Szóbeli

Szekció

Surgical Medicine

Language of the presentation

English

Preferred session

Surgical Medicine

Összefoglaló szövege

Aims:
Preoperative evaluation of living kidney donor candidates involves CT-based morphological and scintigraphy-based functional imaging to select kidneys for nephrectomy. The newly-introduced Photon Counting Detector CT (PCD-CT) offers highly accurate anatomical evaluation and iodine maps from contrast-enhanced phases. Our study aimed to investigate the correlation between renal volumetry and iodine uptake measured by PCD-CT versus split renal function (SRF) determined by dynamic renal scintigraphy, and their impact on kidney selection and postoperative kidney function.

Methods:
We included 88 consecutive potential kidney donor candidates who underwent multiphase PCD-CT scanning and 99mTc-DTPA-based dynamic renal scintigraphy. Cortical renal volume (CRV) and total parenchymal volume (TPV) were calculated based on cortical and total parenchymal segmentation of 176 kidneys. Average iodine concentration in these volumes was also determined. CT-based depth correction assessed split renal function. Among the 88 candidates, 40 (45%) underwent nephrectomy. Serum creatinine levels and eGFR (calculated with the CKD-EPI formula) were measured before and after nephrectomy.

Results:
We found a significant correlation between CRV and post-nephrectomy eGFR (r2=0.32, p=0.0059), as well as between average arterial phase iodine concentration and post-nephrectomy eGFR (r2=0.41, p=0.0014). In a multiple regression model, CRV and arterial iodine concentration were stronger predictors of post-nephrectomy renal function than cSRF (adjusted R-squares: 0.679 vs. 0.417, log-likelihood test p=0.0076).

Conclusion:
Future clinical use of automatic segmentation may eliminate the need for preoperative scintigraphy in living donor evaluations, reducing costs and patient radiation dose.

Funding:
No funding was received.

University

Semmelweis University

Supervisor

Dr. Lénárd Zsuzsanna

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

jóváhagyta

Előadó

9099

Start

10:30

End

13:45