PhD Scientific Days 2025

Poster Session III. - H: Pharmaceutical Sciences and Health Technologies

Formulation of Multiparticulate Metronidazole-Containing Vaginal Drug Delivery Systems

Előadó neve

Ms. Vilimi Zsófia

Neptun code

GTPB42

Előadó munkahelye

Semmelweis University, Department of Pharmaceutics

Előadó telefonszáma

+36204662070

Előadó e-mail címe

vilimi.zsofia@semmelweis.hu

Az előadás címe

Formulation of Multiparticulate Metronidazole-Containing Vaginal Drug Delivery Systems

Szerző(k) neve és munkahelye

Zsófia Vilimi¹, Evelin Schwasta¹, Dóra Farkas¹, Nikolett Kállai-Szabó¹, István Antal¹

1: Semmelweis University, Department of Pharmaceutics

Bemutatás módja

Poszter

Szekció

Poster Session III. - H: Pharmaceutical Sciences and Health Technologies

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Bacterial vaginosis (BV) is a common vaginal infection caused by the disruption of the normal vaginal microbiota, characterized by the overgrowth of anaerobic bacterias. This condition affects millions of women worldwide annually. The pathogenesis of BV is typically associated with the presence of these pathogenic bacteria, a reduction in Lactobacillus species, and an imbalance in the host’s vaginal environment. Such dysbiosis can be triggered by physiological or non-physiological changes. Clinically, BV presents with nonspecific symptoms including vaginal itching, burning, and irritation, which may further lead to dyspareunia and dysuria. Treatment options commonly include locally administered antibiotics such as vaginal tablets and suppositories, as well as oral medications.
The primary objective of our research was to design and develop an innovative multiparticulate vaginal drug delivery system with modified release properties. To achieve this, we employed a fluidized bed coating technique to layer metronidazole-containing dispersion onto inert pellet cores. The pellets coated with Eudragit were embedded in an HPMC-based film. The film was then rolled and encapsulated within gelatin capsules, creating a novel vaginal dosage form.
We conducted in vitro evaluations to characterize the physicochemical properties and drug release profile of the developed formulation. The results demonstrated successful incorporation and stable retention of metronidazole within the film matrix, ensuring controlled and effective drug release.
Our study successfully established a promising new concept for a metronidazole-based vaginal therapy. The innovative formulation techniques applied during development allowed for precise drug loading and sustained release, addressing the limitations of conventional treatments. The positive outcomes from our in vitro assessments support the viability of this drug delivery system and underscore its potential for future clinical applications.
In conclusion, this multiparticulate vaginal dosage form represents a significant advancement in the treatment of bacterial vaginosis, offering improved therapeutic efficacy and patient convenience. Further in vivo studies and clinical trials are warranted to fully explore its benefits and optimize its clinical use.

University

Semmelweis University

Supervisor

István Antal

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7393

Start

14:00

End

14:06