PhD Scientific Days 2025

Poster Session II. - B: Molecular Medicine

Identifying a Possible New Therapeutic Option for Atherosclerosis

Előadó neve

Ms. Sági Stella Márta

Neptun code

G6NO54

Előadó munkahelye

Semmelweis University, Department of Physiology

Előadó telefonszáma

+36307009163

Előadó e-mail címe

sagi.stella@phd.semmelweis.hu

Az előadás címe

Identifying a Possible New Therapeutic Option for Atherosclerosis

Szerző(k) neve és munkahelye

Stella Márta Sági¹, Anna Horváth², Zoltán Jakus¹

1: Semmelweis University, Department of Physiology
2: AnnaHorist Ltd.

Bemutatás módja

Poszter

Szekció

Poster Session II. - B: Molecular Medicine

Language of the presentation

English

Preferred session

Molecular Medicine

Összefoglaló szövege

Introduction: The mechanism of the development and progression of cardiovascular diseases, such as atherosclerosis, is still not fully understood, which is a major health challenge worldwide. The disease develops due to the accumulation of lipid plaques on the walls of blood vessels, leading to thickening and narrowing of the vascular walls. Macrophages have been described as crucial mediators of the atherosclerotic cascade; however, their role has not been fully elucidated.
Aims: Our aim is to improve our understanding of the pathogenesis of atherosclerosis and to develop a new therapeutic option for the treatment of the disease. We aim to achieve these goals through a detailed preclinical study of an experimental agent, ACHA, developed by our collaboration partner, AnnaHorist Ltd.
Methods: We used an immortalized macrophage cell line and tested whether these cells take up the ACHA. We employed the transgenic LDLR -/- mouse model to induce atherosclerosis through a 16-week high-fat diet. Following disease induction, mice received intravenous administration of the ACHA compound. Blood samples were collected to measure cholesterol, LDL, and HDL levels, aortic arches were analyzed for lipid accumulation.
Result: Our findings indicate that macrophages take up the ACHA as early as 5 minutes. Furthermore, our results showed a sex difference in disease progression, more lipid deposition was observed in female mice than in males. Stereomicroscopic images revealed a decrease in aortic plaque formation, suggesting the potential therapeutic effects of ACHA; however, further investigations are needed to optimize its efficacy.
Conclusion: These results suggest that ACHA may have beneficial effects in moderating atherosclerosis progression, although further studies are required to optimize dosage and administration protocols. We would also like to investigate the difference in disease progression between sexes. Our findings contribute to the ongoing exploration of novel treatment strategies for cardiovascular diseases, highlighting the importance of targeted molecular interventions.
Funding: Project No. 2023-2.1.2-Kdp-2023-00016, SE250+ for Stella Márta Sági

University

Semmelweis University

Supervisor

Zoltán Jakus

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8047

Start

18:24

End

18:30