PhD Scientific Days 2025

Conservative Medicine II.

The Role of the „Fatty Pancreas” in Type 2 Diabetes Development

Előadó neve

Dr. Nádasdi Ákos, PhD

Neptun code

AOSW8L

Előadó munkahelye

Institute of Translational Medicine, Semmelweis University

Előadó telefonszáma

+36704507643

Előadó e-mail címe

nadasdi.akos@semmelweis.hu

Az előadás címe

The Role of the „Fatty Pancreas” in Type 2 Diabetes Development

Szerző(k) neve és munkahelye

Ákos Nádasdi Dr.¹, Botond A. Nemes¹, Anikó Somogyi Prof. Dr.², Zoltán Benyó Prof. Dr.¹, Gábor Firneisz Dr.¹

1: Institute of Translational Medicine, Semmelweis University
2: Department of Internal Medicine and Haematology, Semmelweis University

Bemutatás módja

Szóbeli

Szekció

Conservative Medicine II.

Language of the presentation

English

Preferred session

Conservative Medicine

Összefoglaló szövege

Introduction: In our preceding study we assessed associations between intrapancreatic, intrahepatic fat deposition and metabolic factors including prediabetes and type 2 diabetes (T2DM). In contrast to the internationally accepted cut-off value for the liver fat content for „steatotic liver” in metabolic dysfunction associated steatotic liver disease (MASLD) no such cut-off value of the pancreatic fat content (PTGC) is available for the diagnosis of „fatty pancreas”.
Aims: We aimed to further analyze the relationship between PTGC and T2DM and to estabilish a lipid cut-off value associated with T2DM development based on our and published data.
Methods: We used data of 39 participants from our prior study and data of publications available in the literature were included using the following criteria:
• MR based methods used for pancreatic lipid value quantification
• Only adult participants were studied
• Lipid values in prediabetes / T2DM / normal glucose tolerant (NGT) groups were available.
We used meta-analysis to assess the mean difference of lipid values between groups with different glycemic states (NGT-prediabetes-T2DM). After pooling the lipid values of each groups best cut-off point was estabilished using ROC analysis and Youden index. Analyses were performed in R (meta, metafor and ggplot2 packages).
Results: We found 42 further publications according to the inclusion criteria, however n=22 were excluded from the final analysis. During meta-analysis we found significant differences in PTGC values between the glycemic groups (mean difference NGT vs T2DM: 4.11%, p<0.0001; NGT vs prediabetes: 4.02%, p=0.002; prediabetes vs T2DM: 2.51%, p=0.048). We found the best cut-off value of PTGC for NGT vs T2DM: 7.72% (sensitivity=0.94, specificity=0.97).
Conclusion: We found a step-wise increase in PTGC values in the following sequence: NGT – prediabetes – T2DM. We estabilished a PTGC cut-off value of 7.7% with good discrimination capability for NGT and T2DM populations. Further studies are needed to assess the clinical consequences of this metabolic endpoint associated cut-off value for „fatty pancreas”.
Funding: EKÖP24

University

Semmelweis University

Supervisor

Gábor Firneisz Dr.

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

after finishing doctoral studies with absolutorium (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

jóváhagyta

Előadó

1175

Start

16:00

End

16:15