PhD Scientific Days 2025

Poster Session I. - I: Theoretical and Translational Medicine

Fabrication of poly (amino acid) based meshes for enhanced postoperative pain relief

Előadó neve

Mr. Chrysanthou Christodoulos

Neptun code

JBX8VQ

Előadó munkahelye

Semmelweis Egyetem

Előadó telefonszáma

706042650

Előadó e-mail címe

chrischrys10@gmail.com

Az előadás címe

Fabrication of poly (amino acid) based meshes for enhanced postoperative pain relief

Szerző(k) neve és munkahelye

Christodoulos Chrysanthou¹

1: Semmelweis Egyetem

Bemutatás módja

Poszter

Szekció

Poster Session I. - I: Theoretical and Translational Medicine

Language of the presentation

English

Preferred session

Theoretical and Translational Medicine

Összefoglaló szövege

Introduction: Post-operative pain management is a key element of Enhanced Recovery After Surgery (ERAS). Although NSAIDs are frequently used for this purpose, their application is linked to increased risks of nephrotoxicity and gastrointestinal side effects. Similarly, while opioids are another therapeutic option, they can cause several adverse effects such as respiratory depression, nausea, vomiting, constipation, and urinary retention. In contrast, local anesthetics (e.g. lidocaine, bupivacaine) has demonstrated effectiveness in reducing early postoperative pain and improving recovery quality. However, when administered intramuscularly, its analgesic effect typically lasts only up to 90 minutes. The incorporation of local anesthetics into surgical meshes could potentially extend its therapeutic duration, thereby optimizing post-surgical recovery.
Aims: The primary goal of this study was to create a fibrous mesh characterized by specific chemical and physical properties, offering an innovative approach for post-operative pain management.
Methods: Polysuccinimide (PSI) was synthesized via thermal polycondensation of L-aspartic acid, following a standardized protocol. A local anesthetic was mixed with the PSI to produce are working solution. Electrospinning was employed for mesh production, followed by comprehensive assessments of chemical composition, physical morphology, and mechanical characteristics. Analytical techniques included ATR-FTIR spectroscopy, scanning electron microscopy, uniaxial mechanical testing, and UV-Vis spectroscopy.
Results: Successful fabrication of PSI meshes was confirmed through ATR-FTIR spectroscopy. Scanning electron microscopy revealed fiber diameters averaging 450 nm ± 100 nm, indicating a structurally sound mesh. Mechanical testing affirmed the material's suitability for implantation. The drug release studies showed that the majority of the local anesthetic was release within the first 5 minutes of the experiment, however minimal drug release continued for 5 hours.
Conclusion: The synthesized meshes possess properties that support their use as implantable materials. Preliminary UV-Vis spectroscopy data on the drug release profile are promising, with future studies planned to include in vitro cell assays and in vivo animal testing.

University

Semmelweis University

Supervisor

Constantinos Voniatis

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

before finishing undergraduate studies (TDK, MD-PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8034

Start

17:48

End

17:54