PhD Scientific Days 2025

Pathological and Oncological Sciences II.

Body Mass Index and Survival in Endometrial Cancer

Előadó neve

Ms. Karadocsev Éva

Neptun code

A61GXZ

Előadó munkahelye

Semmelweis Univerity - Department of Bioinformatics

Előadó telefonszáma

+36300164582

Előadó e-mail címe

evakaradocsev@gmail.com

Az előadás címe

Body Mass Index and Survival in Endometrial Cancer

Szerző(k) neve és munkahelye

Éva Karadocsev¹, Prof. Dr. Balázs Győrffy¹

1: Semmelweis Univerity - Department of Bioinformatics

Bemutatás módja

Szóbeli

Szekció

Pathological and Oncological Sciences II.

Language of the presentation

Hungarian

Preferred session

Pathological and Oncological Sciences

Összefoglaló szövege

Introduction:
Obesity is commonly linked to the development of endometrial cancer, but its prognostic relevance after diagnosis is still debated. This meta-analysis aimed to evaluate whether higher body mass index (BMI) influences overall survival among patients diagnosed with endometrial cancer.
Aims:
This meta-analysis was conducted to determine whether elevated body mass index (BMI) is associated with increased overall mortality in individuals diagnosed with endometrial cancer.
Methods:
We analyzed 50 BMI-related comparisons across 21 independent studies, all of which reported hazard ratios (HRs) for mortality stratified by BMI category. A random-effects model using inverse variance weighting was applied to estimate the overall effect. Heterogeneity between studies was measured using the I² statistic. To assess potential reporting bias, funnel plot visualization and Egger’s linear regression test were performed.
Results:
The combined HR was 1.25 (95% CI: 1.06–1.46), indicating that higher BMI was associated with an increased risk of death (p < 0.05). Considerable heterogeneity was observed (I² = 97%, p < 0.01), suggesting meaningful variability in effect size between studies. However, neither the funnel plot nor Egger’s test (intercept = 0.69, 95% CI: –1.17 to 2.54; p = 0.47) indicated evidence of publication bias.
Conclusion:
Excess body weight appears to be linked with poorer survival outcomes in individuals with endometrial cancer. These findings support a more integrated approach to post-diagnosis care, where weight status is considered in treatment and follow-up strategies. Future studies should focus on disentangling the role of adiposity-related biological mechanisms and the contribution of body composition.
Funding:This research received no external funding.

University

Semmelweis University

Supervisor

Prof. Dr. Balázs Győrffy

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

jóváhagyta

Előadó

9140

Start

12:45

End

13:00