PhD Scientific Days 2025

Poster Session III. - H: Pharmaceutical Sciences and Health Technologies

Characterization of the Allosteric Effects in the CRM1-RanGTP Complex Formation

Előadó neve

Ms. Czigléczki Janka

Neptun code

AXPT2M

Előadó munkahelye

Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary

Előadó telefonszáma

+36306332307

Előadó e-mail címe

czigleczki.janka@phd.semmelweis.hu

Az előadás címe

Characterization of the Allosteric Effects in the CRM1-RanGTP Complex Formation

Szerző(k) neve és munkahelye

Janka Czigléczki¹, Hyunbum Jang², Ruth Nussinov², Erika Balog¹

1: Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary
2: Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Cancer Innovation Laboratory, National Cancer Institute, Frederick, MD, United States

Bemutatás módja

Poszter

Szekció

Poster Session III. - H: Pharmaceutical Sciences and Health Technologies

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Small GTPase Ran (Ras-related Nuclear protein) is the main regulator of the nucleo-cytoplasmic transport through the nuclear pore complex. It functions as a molecular switch cycling between the GDP-bound inactive, “off” state, and the GTP-bound active, “on” state. Since deregulation of Ran is linked to numerous cancers, understanding the complexity of its regulatory mechanism is critical for drug discovery. One of the partners in the nucleo-cytoplasmic transport is the export receptor CRM1 (chromosome region maintenance 1). CRM1 cooperatively binds RanGTP and cargo in the nucleus. In the transport complex, RanGTP is localized within the ring-like structure of CRM1. In the crystal structures of the CRM1-RanGTP, the structure of the Ran C-terminal segment remains unresolved. Using MD simulations, our goal was to uncover the molecular mechanisms that start from the CRM1-RanGTP binding and lead to the closed macromolecular complex.

This project was partially funded by the TKP2021-EGA-23 provided by the Ministry of Innovation and Technology of Hungary; by federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261201500003I, and by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research.

University

Semmelweis University

Supervisor

Dr. Balog Erika

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7381

Start

15:06

End

15:12