PhD Scientific Days 2025

Poster Session III. - M: Mental Health Sciences

Correlation of depression-related kynurenine pathway PRS and periaqueductal gray matter resting-state connectivity in migraine

Előadó neve

Dr. Gecse Kinga, PhD

Neptun code

X9LFNV

Előadó munkahelye

Department of Pharmacodynamics, Faculty of Pharmaceutical Sciences, Semmelweis University

Előadó telefonszáma

+36202969397

Előadó e-mail címe

gecse.kinga@semmelweis.hu

Az előadás címe

Correlation of depression-related kynurenine pathway PRS and periaqueductal gray matter resting-state connectivity in migraine

Szerző(k) neve és munkahelye

Kinga Gecse¹, Dóra Török¹, Bernadett Nagy¹, Csaba Sándor Aranyi², Miklós Emri², Gabriella Juhász¹

1: NAP3.0-SE Neuropsychopharmacology Research Group, Department of Pharmacodynamics, Faculty of Pharmaceutical Sciences, Semmelweis University
2: Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen

Bemutatás módja

Poszter

Szekció

Poster Session III. - M: Mental Health Sciences

Language of the presentation

Hungarian

Preferred session

Mental Health Sciences

Összefoglaló szövege

Introduction: Around half of migraine patients experience depression symptoms during their lifetime, which is associated with increased disability. The genetic susceptibility is a major factor in the comorbidity of depression with migraine as both conditions have 40-60% heritability. The imbalance of the kynurenine pathway metabolites is another common pathomechanism. In our previous study, depressive symptoms experienced by migraine patients were associated with the functional connectivity network of periaqueductal gray matter (PAG) and brain regions involved in emotion processing.
Aims: Our aim was to identify the potential interplay between the PAG functional connectivity and the genetic susceptibility of kynurenine pathway for depression in migraine patients.
Methods: Twenty-four episodic, migraine without aura patients underwent a resting-state functional magnetic imaging session (3T). Each participant’s functional connectivity map of PAG was determined. The individual genetic risk of kynurenine pathway for depression was described with a polygenic risk score (PRS), which was calculated with LDpred2. The relationship between the depression-related kynurenine PRS and the PAG functional network for depression was examined in a regression model of SPM12.
Results: Positive associateion was found between depression-related PRS and the functional connectivity of PAG with medial orbitofrontral cortex (mOPFC).
Conclusions: Our results suggest that genetic susceptibility of kynurenine pathway for depression is associated with the altered functional connectivity of PAG in migraine patients. The mOPFC plays a role in decision making and avoidance of negative emotional states. In other pain pathologies, weakening of the PAG-mOPFC connection was associated with the success of pain treatment. The depression-related kynurenine PRS with strengthened PAG-mOPFC connectivity may be associated with increased disability in migraine patients experiencing depressive symptoms.
Funding: EKÖP-2024-68, EKÖP-2024-164, 2017-1.2.1-NKP-2017-00002, NAP2022-I-4/2022; TKP2021-EGA-25; OTKA(K143391); ERA PerMed (2019-2.1.7-ERA-NET-2020-00005).

University

Semmelweis University

Supervisor

Gabriella Juhasz, MD, DSc

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

after finishing doctoral studies with absolutorium (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5972

Start

14:18

End

14:24