PhD Scientific Days 2025

Poster Session III. - S: Dental Research

One-year Outcome of Endodontic Retreatment Cases Comparing Chlorine Dioxide and Sodium Hypochlorite: A Randomized Controlled Trial

Előadó neve

Dr. Polyák Melinda

Neptun code

H815SE

Előadó munkahelye

Department of Restorative Dentistry and Endodontics, Semmelweis University, Budapest, Hungary

Előadó telefonszáma

+36305975634

Előadó e-mail címe

polyak.melinda9409@gmail.com

Az előadás címe

One-year Outcome of Endodontic Retreatment Cases Comparing Chlorine Dioxide and Sodium Hypochlorite: A Randomized Controlled Trial

Szerző(k) neve és munkahelye

Melinda Polyák¹, Zsolt M Lohinai¹, János Vág¹, Anna Zurányi¹, Enikő Vasziné Szabó¹

1: Department of Restorative Dentistry and Endodontics, Semmelweis University, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session III. - S: Dental Research

Language of the presentation

English

Preferred session

Dental Research

Összefoglaló szövege

Introduction:
Persistent apical periodontitis affects up to 40% of root-filled teeth. Sodium hypochlorite (NaOCl) is the gold- standard irrigant, yet its efficacy is limited by complex root canal anatomy, and its cytotoxicity remains a concern. While traditional chlorine dioxide is widely used in water and surface disinfection, hyper-pure chlorine dioxide (hClO₂) is a novel, patented formulation developed for medical applications. In vitro studies have shown stronger antimicrobial effects and greater biocompatibility compared to NaOCl, but clinical data are lacking.
Aims:
This randomized controlled trial aimed to compare the one-year clinical and radiographic outcomes of endodontic retreatment using NaOCl or hClO₂ as the irrigant in teeth with apical periodontitis.
Methods:
Thirty-six teeth were randomly allocated to NaOCl (n = 17) or hClO₂ (n = 19) groups. After root canal filling removal, canals were irrigated with 2.5% NaOCl or 0.12% hClO₂. Lateral compaction obturation was completed at a second visit. One year later, all teeth were assessed using the periapical index (PAI) scoring system and visual analog scale (VAS). We used Mann–Whitney U test, binomial logistic regression, and Hodges–Lehmann estimates for median PAI differences for group comparisons.
Results:
All patients completed the one-year recall; all teeth remained functional with no sinus tracts or subjective pain. Failure occurred in three cases per group (OR = 1.14, p = 0.881). Median PAI scores significantly improved from 4.4 to 2.6 in the hClO₂ group (p < 0.001), and from 4.3 to 2.9 in the NaOCl group (p < 0.01). Between group differences in preoperative (p = 0.802), postoperative (p = 0.552) scores, and the change in PAI scores (p = 0.452) were not significant. The Hodges–Lehmann median difference was 0.0 (95% CI: –1.0 to 0.0), indicating that hClO₂ is non-inferior. VAS scores rose only in the hClO₂ group (p < 0.01), but the intergroup difference was not significant (p = 0.196).
Conclusion:
Hyper-pure chlorine dioxide showed comparable one-year healing outcomes to sodium hypochlorite. Although it may cause slightly more postoperative discomfort, its favorable biocompatibility and antimicrobial efficacy suggest it is a promising alternative irrigant when organic tissue dissolution is not needed.
Funding: None

University

Semmelweis University

Supervisor

Enikő Vasziné Szabó

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9166

Start

14:24

End

14:30