PhD Scientific Days 2025

Poster Session II. - U: Cardiovascular Medicine and Research

Delineating healthy and pathological cardiovascular aging in the UK Biobank

Előadó neve

Dr. Szabo Liliana, PhD

Előadó munkahelye

SE Heart and Vascular Centre

Előadó telefonszáma

+36304843367

Előadó e-mail címe

sz.liliana.e@gmail.com

Az előadás címe

Delineating healthy and pathological cardiovascular aging in the UK Biobank

Szerző(k) neve és munkahelye

Liliana Szabo¹, Jackie Cooper², Dorina-Gabriela Condurache², Dorottya Balla¹, Hajnalka Vago¹, Bela Merkely¹, Steffen E. Petersen², Zahra Raisi-Estabragh²

1: Semmelweis Univeristy Heart and Vascular Centre
2: William Harvey Research Institute, Queen Mary University of London

Bemutatás módja

Poszter

Szekció

Poster Session II. - U: Cardiovascular Medicine and Research

Language of the presentation

English

Preferred session

Cardiovascular Medicine and Research

Összefoglaló szövege

Background: Cardiovascular aging is a key contributor to ill health and mortality, with distinct differences between healthy and pathological aging. Vascular risk factors (VRFs) and cardiovascular diseases (CVDs) accelerate these aging processes, impacting the structure and function of the heart. However, the specific determinants of these variations remain poorly understood.
Objective: This study aims to delineate the effects of aging on myocardial and vascular structures using comprehensive imaging data from the UK Biobank, and to assess how VRFs and CVDs modify these age-related cardiovascular phenotypes.
Methods: We analyzed cardiovascular magnetic resonance (CMR) data from UK Biobank participants, stratified by sex and presence of VRFs (hypertension, obesity, diabetes, high cholesterol, smoking) and CVDs (ischaemic heart disease, heart failure, arrhythmias, valvular heart disease, non-ischaemic cardiomyopathy, stroke, vascular dementia, or peripheral vascular disease). Linear regression models were used to examine the relationships between age, VRFs, CVDs, and cardiovascular metrics.
Results: The study included 61,266 participants (52% women), aged 44–85 years. Common vascular risk factors (VRFs) were smoking (38%), high cholesterol (36%), and hypertension (33%), with 14% having cardiovascular disease (CVD). Among 24,805 healthy participants, aging was associated with lower LV and RV volumes, reduced LVMi (men: β=-0.020; women: β=-0.004), increased EDWT (more in women), and greater concentricity. Higher age was associated with slightly higher LVEF and LVGCS, and reduced LVGLS (M: -0.007 [-0.010 to -0.004]; F: -0.020 [-0.022 to -0.017]). Participants with VRFs (n=28,047) exhibited similar aging trends but with higher concentricity and more pronounced atrial enlargement. In those with CVD (n=8,414), systolic function declined with age, particularly in men (GLS: -0.016 [-0.021 to -0.011]). Hypertension and obesity promoted concentric remodeling, while diabetes drove reduced volumes and mass. Physical activity had protective effects (concentricity β: -0.03 [-0.04 to -0.03]).
Conclusion: This large, sex-stratified study provides comprehensive insights into the cardiovascular aging process, highlighting the importance of early intervention and lifestyle modifications to mitigate age-related structural deterioration of the heart.
Funding: EKÖP-2024-272

University

Semmelweis University

Supervisor

Hajnalka Vago

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

after finishing doctoral studies with absolutorium (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4153

Start

19:12

End

19:18