PhD Scientific Days 2025

Poster Session III. - R: Neurosciences

Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons

Előadó neve

Mr. Orosz Áron

Neptun code

B21UA1

Előadó munkahelye

Institute of Experimental Medicine

Előadó telefonszáma

+36204266165

Előadó e-mail címe

orosz.aron@koki.hun-ren.hu

Az előadás címe

Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons

Szerző(k) neve és munkahelye

Áron Orosz¹, Virág Takács¹, Zsuzsanna Bardóczi¹, Abel Major¹, Luca Tar¹, Gábor Nyiri¹

1: Institute of Experimental Medicine

Bemutatás módja

Poszter

Szekció

Poster Session III. - R: Neurosciences

Language of the presentation

English

Preferred session

Neurosciences

Összefoglaló szövege

GABAergic inhibitory neurons fundamentally shape the activity and plasticity of cortical circuits. A major subset of these neurons contains somatostatin (SOM); these cells play crucial roles in neuroplasticity, learning and memory in many brain areas including the hippocampus, and are implicated in several neuropsychiatric diseases and neurodegenerative disorders. Two main types of SOM-containing cells in area CA1 of the hippocampus are oriens-lacunosum-moleculare (OLM) cells and hippocampo-septal cells. These cell types show many similarities in their soma-dendritic architecture, but they have different axonal targets, display different activity patterns in vivo and are thought to have distinct network functions. However, a complete understanding of the functional roles of these interneurons requires a precise description of their intrinsic computational properties and their synaptic interactions. In the current study we generated, analyzed and make available several key datasets that enable a quantitative comparison of various anatomical and physiological properties of OLM and HS cells. The dataset includes detailed scanning electron microscopy-based 3-dimensional reconstructions of OLM and HS cells along with their excitatory and inhibitory synaptic inputs. Combining this core dataset with other anatomical data, patch-clamp electrophysiology and compartmental modeling, we examined the precise morphological structure, inputs, outputs, and basic physiological properties of these cells. Our results highlight key differences between OLM and HS cells, particularly regarding the density and distribution of their synaptic inputs and mitochondria. For instance, we estimated that an OLM cell receives about 8300, whereas an HS cell about 14800 synaptic inputs, about 16% of which are GABAergic. Our data and models provide insight into the possible basis of the different functionality of OLM and HS cell types and supply essential information for more detailed functional models of these neurons and the hippocampal network.

The research was founded by University Research Scholarship Program, of the Ministry for Innovation and Technology and the Ministry of Human Capacities - EKÖP-2024-214.

University

Semmelweis University

Supervisor

Dr. Nyiri Gábor

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7977

Start

15:00

End

15:06