PhD Scientific Days 2025

Poster Session III. - V: Cardiovascular Medicine and Research

Structural Impact of High- and Very High-Power Short-Duration Ablation on Pulmonary Veins and Remodeling of Adjacent Adipose Tissue

Előadó neve

Dr. Boussoussou Melinda

Előadó munkahelye

Semmelweis University Heart and Vascular Center

Előadó telefonszáma

06206632859

Előadó e-mail címe

melinda.b.md@gmail.com

Az előadás címe

Structural Impact of High- and Very High-Power Short-Duration Ablation on Pulmonary Veins and Remodeling of Adjacent Adipose Tissue

Szerző(k) neve és munkahelye

Melinda Boussoussou¹, Borbála Vattay¹, Milán Vecsey-Nagy¹, Bálint Szilveszter¹, Vivien Nagy-Klaudia¹, István Osztheimer¹, Zoltán Salló¹, Béla Merkely¹, László Gellér¹, Nándor Szegedi¹

1: Semmelweis University Heart and Vascular Center

Bemutatás módja

Poszter

Szekció

Poster Session III. - V: Cardiovascular Medicine and Research

Language of the presentation

English

Preferred session

Cardiovascular Medicine and Research

Összefoglaló szövege

Introduction: High-power (HPSD) and very high-power short-duration (vHPSD) ablation strategies enhance pulmonary vein isolation (PVI) efficiency in atrial fibrillation (AF). The HPSD-Remap trial compared 50W (HPSD) and 90W (vHPSD) ablation. This sub-analysis aimed to evaluate pulmonary vein stenosis (PVS) and peri-pulmonary vein adipose tissue (PPVAT) remodeling using pre- and post-ablation cardiac CT angiography (CTA) to assess thermal effects.

Methods: This prospective, randomized single-center study enrolled patients with symptomatic paroxysmal or persistent AF, treated with either 50W (n=20) or 90W (n=20) ablation. All participants underwent baseline and 3-month follow-up CTA imaging. Pulmonary vein size and PPVAT features—attenuation, gradient, and volume were measured.

Results: Median age was 67.5 [59.0–70.5] years in the HPSD group and 65.0 [61.0–68.0] in the vHPSD group; BMI was 28.7 in both. Among 240 veins analyzed, vHPSD resulted in significantly greater reductions in PV area and diameter (p<0.05), though with small effect sizes. PPVAT attenuation and volume changes did not differ significantly. However, PPVAT gradient was markedly increased with vHPSD (p<0.001, r=0.89), and showed a trend toward association with AF recurrence (p=0.06).

Conclusion: vHPSD ablation induced more substantial PV narrowing and significant alterations in PPVAT gradient, suggesting deeper thermal penetration. Gradient changes may offer potential as a biomarker for ablation response and AF recurrence risk.

Funding: EKÖP-Cooperative Doctoral Program- University Researchers’ Scholarship Program, EKÖP-2024-187

University

Semmelweis University

Supervisor

Dr. Nándor Szegedi

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

after finishing doctoral studies with absolutorium (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4775

Start

14:06

End

14:12