PhD Scientific Days 2025

Poster Session III. - V: Cardiovascular Medicine and Research

The Impact of Coronary Computed Tomography on Statin Allocation in Stable Chest Pain Patients

Előadó neve

Dr. Borbála Vattay

Neptun code

YJSHVO

Előadó munkahelye

Heart and Vascular Center Semmelweis University

Előadó telefonszáma

06309013305

Előadó e-mail címe

bori.vattay@gmail.com

Az előadás címe

The Impact of Coronary Computed Tomography on Statin Allocation in Stable Chest Pain Patients

Szerző(k) neve és munkahelye

Borbála Vattay¹, Melinda Boussoussou¹, Milán Vecsey-Nagy², Pál Maurovich-Horvat³, György Rokszin⁴, Ibolya Fábián⁴, Béla Merkely¹, Márton Kolossváry⁵, Bálint Szilveszter¹

1: Heart and Vascular Center Semmelweis University
2: Heart and Vascular Center Semmelweis University, Medical University of South Carolina, Charleston, SC, USA
3: Medical Imaging Center, Semmelweis University
4: RxTarget Ltd, Szolnok, Hungary
5: Gottsegen National Cardiovascular Center, Physiological Controls Research Center, University Research and Innovation Center, Óbuda University

Bemutatás módja

Poszter

Szekció

Poster Session III. - V: Cardiovascular Medicine and Research

Language of the presentation

Hungarian

Preferred session

Cardiovascular Medicine and Research

Összefoglaló szövege

Introduction: Statin therapy plays a fundamental role in reducing LDL-cholesterol and preventing the progression of coronary artery disease (CAD). Coronary CTA (CCTA) can provide personalized risk assessment and optimize secondary prevention therapy based on CAD phenotypes.
Aim: To assess the role of CCTA on statin allocation and to define the predictors of statin initiation following CCTA.
Methods: Stable chest pain patients who underwent CCTA to assess CAD were evaluated. Coronary calcium score (CACS), segment involvement score (SIS) and stenosis severity were evaluated. We described statin use as redeeming a prescription for a statin at any time of the study period. We created four statin treatment groups: pre-CCTA, post-CCTA, pre-and post-CCTA or no statin intake. Differences among the groups and predictors of statin treatment decision after CCTA was analyzed.
Results: In total, 11,026 patients (mean age 58.6 ± 11.9 years, 54.7% male, mean BMI of 28.3 ± 4.9 kg/m2) were analyzed. Overall, 14% of patients stopped, 11% initiated, 40% continued statin therapy after CCTA, while 34% were not treated with statins during the study period. We detected significantly higher rates of CACS>400, SIS>4 and obstructive CAD among patients on statin therapy after CCTA, as compared with patients with statin therapy only before CCTA or no statin therapy at all (all p<0.001). Patients who were on statins only pre-CCTA had significantly lower obstructive stenosis rates (16.1% vs. 39.3%) and SIS (2.8 ± 2.8 vs. 4.2 ± 3.2) as compared to patients who were treated only post-CCTA (p<0.05 for all). We found that all assessed plaque parameters consistently demonstrated a significant association with treatment decisions.
Conclusion: CCTA significantly impacts allocation of statin therapy by providing direct assessment of CAD.
Funding: Supported by the EKÖP-2024-180 New National Excellence Program of the Ministry for Culture and Innovation fromthe source of the National Research, Development and Innovation Fund.

University

Semmelweis University

Supervisor

Bálint Szilveszter MD PhD

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

after finishing doctoral studies with absolutorium (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4778

Start

14:18

End

14:24