PhD Scientific Days 2025

Poster Session I. - A: Molecular Medicine

BeWo derived extracellular vesicles regulate T cell differentiation by down-regulation of IL- 6Rα expression on CD4+ T lymphocytes

Előadó neve

Nagy Bence

Előadó munkahelye

Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary

Előadó e-mail címe

nagy.bencep94@gmail.com

Az előadás címe

BeWo derived extracellular vesicles regulate T cell differentiation by down-regulation of IL- 6Rα expression on CD4+ T lymphocytes

Szerző(k) neve és munkahelye

B. Nagy¹, N. Fekete¹, E.I. Buzás¹, Á. Kovács¹, É. Pállinger¹

1: Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session I. - A: Molecular Medicine

Language of the presentation

English

Összefoglaló szövege

Maternal immune tolerance requires the action of regulatory T cells at the feto-maternal interface.
Their de novo differentiation is influenced by cellular interactions and the local cytokine milieu.
Trophoblast-derived medium size extracellular vesicles (TEVs) bind to peripheral T lymphocytes and have an effect on T cell function. We assume that TEVs regulate the local T cell differentiation through the regulation of local cytokine effects.
Cytokine secretion and IL6-Rα expression of pregnants’ lymphocytes were investigated in BeWo choriocarcinoma cell - lymphocyte co-culture model system. We demonstrated that BeWolymphocyte interaction induced IL-6 production and down-regulation of IL-6Rα on CD4+ T cells.
BeWo derived medium size extracellular vesicles (EVs) caused a typical shift in the cytokine production of CD4+ lymphocytes: this EV binding induced IL-10 production but neither IL-17 nor IFNα could be detected. We concluded that BeWo derived EVs contribute to the development and maintenance of de novo regulatory T lymphocyte differentiation, through the regulation of both
local cytokine production and IL-6 sensitivity of the lymphocytes.

University

Semmelweis University

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7477

Start

17:40

End

17:45