PhD Scientific Days 2026

Health Sciences 1.

State-specific interaction networks between goblet cells and extracellular vesicles of Bacteroides thetaiotaomicron in Crohn's disease

Előadó neve

Mr. Simon, Viktor

Neptune code

EE4YLU

Előadó munkahelye

Semmelweis University, Faculty of Health Sciences

Előadó telefonszáma

+36706362270

Előadó e-mail címe

simonviktor23@gmail.com

Az előadás címe

State-specific interaction networks between goblet cells and extracellular vesicles of Bacteroides thetaiotaomicron in Crohn's disease

Szerző(k) neve és munkahelye

Simon Viktor¹

1: Semmelweis University, Faculty of Health Sciences

Bemutatás módja

Szóbeli

Szekció

Health Sciences 1.

Language of the presentation

Hungarian

Preferred session

Health Sciences

Összefoglaló szövege

Introduction: Damage to the intestinal barrier and thinning of the mucus layer play a key role in the pathogenesis of Crohn's disease. The function of goblet cells, which are responsible for mucus production, is significantly influenced by human-microbiota interactions. Bacteroides thetaiotaomicron, a known member of the human microbiota, influences the regulation of the mucus layer and intestinal barrier, in which bacterial extracellular vesicles play an important mediating role.
Aim: The aim of our study is to explore human-microbiota interactions related to B. thetaiotaomicron extracellular vesicles affecting goblet cells in healthy populations and in Crohn's disease, and to characterize these interactions in a condition-specific functional manner.
Methods: Differentially expressed genes were identified based on transcriptomic data. The microbial side was represented by the proteome associated with B. thetaiotaomicron extracellular vesicles. Bacteria-human protein-protein interactions were predicted using the MicrobioLink pipeline and then linked to human gene expression differences using a network-based approach. The affected networks were subjected to pathway enrichment analysis.
Results: We identified numerous human-microbiota protein-protein interactions in the goblet cells of Crohn's disease patients, which were primarily associated with inflammatory signaling pathways, NF-κB-related processes, and regulated cell death. In contrast, in healthy individuals, pathways related to the cell cycle, vesicular transport, and cellular homeostasis dominated.
Conclusions: Our results suggest that human-microbiota interactions associated with extracellular vesicles from B. thetaiotaomicron form state-specific functional networks in goblet cells. These findings may contribute to the molecular-level understanding of goblet cell dysfunction and intestinal barrier damage and may serve as a basis for further experimental studies.
Funding: The Ministry of Culture and Innovation’s University Research Scholarship Programme with code number 2025-2.1.1-EKÖP-2025-00014 was created with the support of the National Research, Development and Innovation Fund.

University

Semmelweis University

Supervisor

Dr. Földvári - Nagy Lászlóné Dr. Lenti Katalin, Dr. Földvári - Nagy László, Dr. Éliás Anna Júlia

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

before finishing undergraduate studies (TDK, MD-PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem hagyta jóvá

Előadó

9670

Start

15:00

End

15:10