PhD Scientific Days 2026

Poster Session 2.G - Pharmaceutical Sciences and Health Technologies

A new insight on the potentiometric log P determination of therapeutically important opioids and fluoroquinolones

Előadó neve

Ms. Malik, Alaa

Neptune code

D0K8FR

Előadó munkahelye

Semmelweis University

Előadó telefonszáma

0036704016428

Előadó e-mail címe

alaa.malik@phd.semmelweis.hu

Az előadás címe

A new insight on the potentiometric log P determination of therapeutically important opioids and fluoroquinolones

Szerző(k) neve és munkahelye

Alaa Malik¹, Béla Noszál¹, Károly Mazák¹

1: Semmelweis University, Department of Pharmaceutical Chemistry, Hőgyes E. u. 9., H-1092 Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session 2.G - Pharmaceutical Sciences and Health Technologies

Language of the presentation

English

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction:
Lipophilicity is a crucial physicochemical property that affects ADME behavior, toxicity, and adverse effects of drugs. It is commonly quantified using partition coefficients, typically determined in octanol–water systems. Reliable determination of partition coefficients and their logarithms (log P) is essential in pharmaceutical research and drug design. However, traditional methods such as the shake-flask procedure, chromatographic techniques, or potentiometric titration with specialized instruments are often time-consuming or require expensive equipment.
Aims:
This study aims to demonstrate that potentiometric titration using a simple and affordable titrator can serve as a practical and efficient alternative method for evaluating lipophilicity.
Methods
The partitioning behavior of opioids and fluoroquinolones was investigated by determining their apparent protonation macro- and microconstants in aqueous/organic biphasic systems. Titrations were performed under controlled aqueous–organic phase ratios with optimized equilibration times to ensure accurate electrode response. Species-specific log p values for amphoteric compounds were calculated based on shifts in apparent protonation constants in the presence of the organic solvent at different phase ratios, using established equations.
Results:
The results showed that log p values derived from potentiometric measurements using species-specific microconstants are highly reproducible and internally consistent. These values were found to be more reliable than those obtained using macroconstants, which has been the only approach reported in the literature until now.
Conclusion:
This study demonstrates that accurate lipophilicity assessment does not require costly or specialized equipment. A standard, low-cost potentiometric setup can provide accurate, reliable, and robust lipophilicity data under moderate cost conditions.
Funding:
This research was supported by the Stipendium Hungaricum scholarship.

University

Semmelweis University

Supervisor

Béla Noszál

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7990

Start

18:54

End

18:57