PhD Scientific Days 2026

Poster Session 1.S - Conservative Medicine

Region-Specific and Severity-Associated Alterations of the Skin Microbiome in Hailey-Hailey Disease

Előadó neve

Dr. Metyovinyi, Zseraldin

Neptune code

M9UZ0W

Előadó munkahelye

Semmelweis University Department of Dermatology, Venereology and Dermatooncology

Előadó telefonszáma

06304801850

Előadó e-mail címe

metyovinyi.zseraldin@gmail.com

Az előadás címe

Region-Specific and Severity-Associated Alterations of the Skin Microbiome in Hailey-Hailey Disease

Szerző(k) neve és munkahelye

Zseraldin Metyovinyi¹, Dóra Plázár¹, Norbert Kiss¹, András Bánvölgyi¹, Balázs Mayer¹, Eszter Ostorházi², Márta Medvecz¹

1: Semmelweis University Department of Dermatology, Venereology and Dermatooncology
2: Semmelweis University Institute of Medical Microbiology

Bemutatás módja

Poszter

Szekció

Poster Session 1.S - Conservative Medicine

Language of the presentation

Hungarian

Preferred session

Conservative Medicine

Összefoglaló szövege

Introduction: Hailey-Hailey disease (HHD) is a rare acantholytic genodermatosis that affects the bilateral flexural areas, presenting with vesicles and erosive plaques. Alterations of the skin microbiome may contribute to disease exacerbations at predilection sites.
Aims: This study aimed to characterize the clinical, genetic, and microbiome features in patients with HHD.
Methods: We analyzed the skin microbiome of three predilection sites in eight genetically and/or histologically confirmed HHD patients (female-to-male ratio, 7:1; mean age:48 years) and healthy controls (female-to-male ratio:5:1; mean age:47 years) using 16S rRNA (V3-V4) sequencing followed by analysis on the CosmosID bioinformatics platform.
Results: Region-specific taxonomic and functional dysbiosis was observed in HHD, predominantly in lesional but also in clinically non-lesional skin. The axillary region showed increased abundance of Staphylococcus aureus and Pseudomonas aeruginosa, submammary samples were dominated by Finegoldia magna and Anaerococcus sp., whereas the inguinal microbiome was characterized by anaerobic taxa. Microbial alterations were most prominent in lesional and clinically more severe disease.
Conclusion: The observed dysbiosis can potentially influence the HHD phenotype, exacerbation, and persistence of the lesions in predilection areas. These findings suggest that microbial imbalance is not merely secondary to the skin lesions but may represent a predisposing microenvironment in flexural skin.
Funding: This work was supported by grants from the National Research, Development and Innovation Office of Hungary—NKFIH FK_131916, 2019 (Semmelweis University, Márta Medvecz.).

University

Semmelweis University

Supervisor

Márta Medvecz

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9682

Start

16:48

End

16:51